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• W2473683827 abstract "Objectives: To study the effect of oral administration of grape seed oil (GSO) against carbontetrachloride (CCl 4 )-induced hepatotoxicity in rats. Methods: Liver damage was induced in male Wistar rats (150–250 g) by administering CCl 4 (0.5 ml/kg, i.p.) once per day for 7 days and the extent of damage was studied by assessing biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum and concentrations of malondialdehyde (MDA), hydroperoxides, glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and total protein (TP) in liver. The effect of co-administration of GSO (3.7 g/kg, orally) on the above parameters was further investigated and compared with a vitamin E (100 mg/kg, orally) treated group. Histopatholgical studies of the experimental animals were also done. Results: Oral administration of GSO (3.7 g/kg, body weight orally) for 7 days resulted in a significant reduction in serum AST, ALT, and ALP levels and liver MDA and hydroperoxides and significant improvement in glutathione, SOD, CAT, and TP, when compared with CCl 4 damaged rats. The antioxidant effect of GSO at 3.7 g/kg for 7 days was found to be comparable with vitamin E (100 mg/kg, orally) in CCl 4 -treated rats. Profound fatty degeneration, fibrosis, and necrosis observed in the hepatic architecture of CCl 4 -treated rats were found to acquire near – normalcy in drug coadministered rats. Conclusion: The GSO has protected the liver from CCl 4 damage. Probable mechanism of action may be due to the protection against oxidative damage produced by CCl 4 . USA. Carbontetrachloride (CCl 4 ) was obtained from E. Merck (India) Ltd., Mumbai. Thiobarbituric acid (TBA), 5,51-dithiobis-2-nitrobenzoic acid (DTNB), and glutathione (GSH) were obtained from Sigma, USA. Vitamin E was obtained from Hi Media Pvt., Ltd., Mumbai. All chemicals used in the study were of analytical grade. Experimental animals Male Wistar albino rats (150–250 g) were used. The animals were acclimatized to laboratory conditions for 5 days prior to the experiments and had access to food and water ad libitum. Before commencing the work, permission from Institutional Animal Ethics Committee was obtained. Selection of dose of GSO The human dose of GSO was converted in to the animal dose using the standard dose-converting table. [7] Further, the dose for the hepatoprotective studies was adjusted based on the observation during the toxicity studies. The GSO at a dose of 3.7 g/kg (4 ml/kg) was administered orally to study the hepatoprotective activity. An emulsion of GSO was prepared using 2% gum acacia by wet gum method. Experimental design Acute toxicity studies Wistar Albino rats (150–250 g) maintained under standard laboratory conditions were used. A total of five animals" @default.
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• W2473683827 title "Antihepatotoxic effect of grape seed oil in rat Antihepatotoxic effect of grape seed oil in rat Antihepatotoxic effect of grape seed oil in rat Antihepatotoxic effect of grape seed oil in rat Antihepatotoxic effect of grape seed oil in rat" @default.
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