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• W2473699571 abstract "We previously conducted a pilot study that reported the safety of isosorbide dinitrate boluses for elderly emergency patients with acute heart failure syndrome. To assess the temporal trend in the rate of elderly patients treated with isosorbide dinitrate, and to evaluate subsequent outcome differences. This was a single-centre study. We compared patients aged > 75 years who attended the emergency department with a primary diagnosis of acute pulmonary oedema in the years 2007 and 2014. The primary endpoint was the rate of patients who received isosorbide dinitrate boluses in the emergency department. Secondary endpoints included in-hospital mortality, need for intensive care and length of stay. We analysed 368 charts, 232 from patients included in 2014 (63%) and 136 in 2007 (37%). The mean age was 85 ± 6 years in both groups. There was a significant rise in the rate of patients treated with isosorbide dinitrate between 2007 and 2014: 97 patients (42%) in 2014 vs. 24 patients (18%) in 2007 (P < 0.01). Comparing the two periods, we report similar in-hospital mortality rates (8% vs. 11%; P = 0.5), rates of admission to the intensive care unit (13% vs. 17%; P = 0.3) and lengths of stay (10 days in both groups). We observed a significant rise in the rate of elderly patients treated with isosorbide dinitrate boluses for acute heart failure. However, we did not observe any significant improvement in outcomes. Nous avons publié précédemment une étude rapportant la sécurité d’utilisation du dinitrate d’isosorbide (ISDN) chez les patients de plus de 75 ans aux urgences. Évaluer l’évolution temporelle du taux de patients âgés traités par ISDN aux urgences pour œdème aigu pulmonaire (OAP), et l’impact en terme de pronostic. Étude monocentrique rétrospective. Nous avons comparé les patients de plus de 75 ans admis aux urgences pour OAP sur les années 2007 et 2014. Le critère de jugement principal était le traitement par bolus intraveineux d’ISDN. Les critères secondaires incluaient la mortalité hospitalière, l’admission en soins intensifs, et la durée d’hospitalisation. Nous avons analysé 368 dossiers – 232 en 2014 (63 %) et 136 en 2007 (37 %). L’âge moyen était de 85 ans (écart-type 6) dans les deux groupes. Il y avait une augmentation significative du taux de patients traités par ISDN en 2014 : 97 patients (42 %) vs 24 (18 %) en 2007. La mortalité hospitalière, l’admission en soins intensifs et la durée d’hospitalisation étaient inchangées entre les deux périodes. Le taux de patients traités par ISDN a bien augmenté avec le temps, sans que nous n’ayons pu en montrer un impact pronostique." @default.
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• W2473699571 date "2016-08-01" @default.
• W2473699571 modified "2023-10-10" @default.
• W2473699571 title "Temporal trends in nitrate utilization for acute heart failure in elderly emergency patients: A single-centre observational study" @default.
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• W2473699571 doi "https://doi.org/10.1016/j.acvd.2016.01.014" @default.
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