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- W2473722134 abstract "Background: The serum procollangen-III-N-terminal peptide (PIIINP) is assumed to be a useful marker for liver fibrosis. This study evaluated the change in the PIIINP, and identified the predictive factors for treatment response in chronic hepatitis B patients (CHB) with cirrhosis during entecavir (ETV) treatment. Methods: A total of 308 patients with clinically diagnosed cirrhosis were treated with ETV for ≥ 12 months. The serum PIIINP levels were measured at baseline and after 12 months of ETV treatment. Virological response (VR), biochemical response, and serological response were assessed after 12 months of treatment. VR was defined as HBV DNA < 2,000 copies/mL until June, 2008 and <20 IU/mL after July, 2008. Results: Two hundred and ten (68.2%) patients had compensated cirrhosis and remaining (31.8%) patients had decompensated cirrhosis. VR was achieved in 77.1% and 69.4% of patients, and alanine aminotransferase (ALT) normalization was observed in 67.6% and 77.6% of patients with compensated and decompensated cirrhosis, respectively (P=0.145 and P=0.074). Hepatitis B e-antigen (HBeAg) loss was noted at 15.2% and 22.4%, and HBeAg seroconversion was noted at 2.9% and 4.1 % of patients with compensated and decompensated cirrhosis, respectively (P=0.121 and P=0.399). Univariate analysis showed that high baseline ALT (P=0.001), low baseline HBV DNA (P=0.000), HBeAg negativity (P=0.001), serum PIIINP level after 12 months (P=0.010) and change of serum PIIINP level (P=0.049) were predictive factors for achievement of VR. Multivariate analysis showed that high baseline ALT (P=0.016), low HBV DNA level (P=0.000), and low serum PIIINP level after 12 months (P=0.020) were independent predictive factors for achievement of VR. Conclusions: Serum PIIINP level during ETV treatment is useful for predictive the treatment response in CHB patients with cirrhosis." @default.
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- W2473722134 date "2013-01-01" @default.
- W2473722134 modified "2023-09-22" @default.
- W2473722134 title "LC : Change in Procollangen III N-Terminal Peptide as a Predictor of Virological Response in Chronic Hepaitits B Patients with Cirrhosis during Entecavir Therapy" @default.
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