Matches in SemOpenAlex for { <https://semopenalex.org/work/W2473772223> ?p ?o ?g. }
- W2473772223 endingPage "58" @default.
- W2473772223 startingPage "48" @default.
- W2473772223 abstract "Istradefylline (KW-6002), an adenosine A2A receptor antagonist, is used adjunct with optimal doses of L-3,4-dihydroxyphenylalanine (l-DOPA) to extend on-time in Parkinson's disease (PD) patients experiencing motor fluctuations. Clinical application of istradefylline for the management of other l-DOPA-induced complications, both motor and non-motor related (i.e. dyskinesia and cognitive impairments), remains to be determined. In this study, acute effects of istradefylline (60–100 mg/kg) alone, or with optimal and sub-optimal doses of l-DOPA, were evaluated in two monkey models of PD (i) the gold-standard 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model of parkinsonian and dyskinetic motor symptoms and (ii) the chronic low dose (CLD) MPTP-treated macaque model of cognitive (working memory and attentional) deficits. Behavioural analyses in l-DOPA-primed MPTP-treated macaques showed that istradefylline alone specifically alleviated postural deficits. When combined with an optimal l-DOPA treatment dose, istradefylline increased on-time, enhanced therapeutic effects on bradykinesia and locomotion, but exacerbated dyskinesia. Istradefylline treatment at specific doses with sub-optimal l-DOPA specifically alleviated bradykinesia. Cognitive assessments in CLD MPTP-treated macaques showed that the attentional and working memory deficits caused by l-DOPA were lowered after istradefylline administration. Taken together, these data support a broader clinical use of istradefylline as an adjunct treatment in PD, where specific treatment combinations can be utilised to manage various l-DOPA-induced complications, which importantly, maintain a desired anti-parkinsonian response." @default.
- W2473772223 created "2016-07-22" @default.
- W2473772223 creator A5004190849 @default.
- W2473772223 creator A5030169711 @default.
- W2473772223 creator A5032345649 @default.
- W2473772223 creator A5038518123 @default.
- W2473772223 creator A5075080019 @default.
- W2473772223 creator A5084269914 @default.
- W2473772223 creator A5084439989 @default.
- W2473772223 date "2016-11-01" @default.
- W2473772223 modified "2023-10-03" @default.
- W2473772223 title "An evaluation of istradefylline treatment on Parkinsonian motor and cognitive deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque models" @default.
- W2473772223 cites W1493115321 @default.
- W2473772223 cites W1530032997 @default.
- W2473772223 cites W1571001168 @default.
- W2473772223 cites W1603297402 @default.
- W2473772223 cites W1778152931 @default.
- W2473772223 cites W1965959650 @default.
- W2473772223 cites W1966684691 @default.
- W2473772223 cites W1967054290 @default.
- W2473772223 cites W1971002934 @default.
- W2473772223 cites W1972010893 @default.
- W2473772223 cites W1974588747 @default.
- W2473772223 cites W1978559289 @default.
- W2473772223 cites W1978647688 @default.
- W2473772223 cites W1980473651 @default.
- W2473772223 cites W1981821582 @default.
- W2473772223 cites W1982535961 @default.
- W2473772223 cites W1986174590 @default.
- W2473772223 cites W1988179423 @default.
- W2473772223 cites W1990269363 @default.
- W2473772223 cites W1994348655 @default.
- W2473772223 cites W1999362064 @default.
- W2473772223 cites W2003471045 @default.
- W2473772223 cites W2009631046 @default.
- W2473772223 cites W2010478807 @default.
- W2473772223 cites W2010485061 @default.
- W2473772223 cites W2014175065 @default.
- W2473772223 cites W2016109926 @default.
- W2473772223 cites W2022636759 @default.
- W2473772223 cites W2025009858 @default.
- W2473772223 cites W2026475932 @default.
- W2473772223 cites W2028129201 @default.
- W2473772223 cites W2028285705 @default.
- W2473772223 cites W2030108063 @default.
- W2473772223 cites W2031170958 @default.
- W2473772223 cites W2034588648 @default.
- W2473772223 cites W2035286056 @default.
- W2473772223 cites W2035473759 @default.
- W2473772223 cites W2035725338 @default.
- W2473772223 cites W2037673105 @default.
- W2473772223 cites W2040227196 @default.
- W2473772223 cites W2043409056 @default.
- W2473772223 cites W2044490788 @default.
- W2473772223 cites W2048501744 @default.
- W2473772223 cites W2054619289 @default.
- W2473772223 cites W2056890984 @default.
- W2473772223 cites W2060241252 @default.
- W2473772223 cites W2062147269 @default.
- W2473772223 cites W2063293639 @default.
- W2473772223 cites W2065226845 @default.
- W2473772223 cites W2065444472 @default.
- W2473772223 cites W2070912312 @default.
- W2473772223 cites W2075621586 @default.
- W2473772223 cites W2077698652 @default.
- W2473772223 cites W2086043974 @default.
- W2473772223 cites W2088277236 @default.
- W2473772223 cites W2088525880 @default.
- W2473772223 cites W2089232386 @default.
- W2473772223 cites W2089821581 @default.
- W2473772223 cites W2093452723 @default.
- W2473772223 cites W2095527991 @default.
- W2473772223 cites W2099652807 @default.
- W2473772223 cites W2101890054 @default.
- W2473772223 cites W2111597060 @default.
- W2473772223 cites W2115222037 @default.
- W2473772223 cites W2115639304 @default.
- W2473772223 cites W2119450744 @default.
- W2473772223 cites W2128822240 @default.
- W2473772223 cites W2131371182 @default.
- W2473772223 cites W2136306454 @default.
- W2473772223 cites W2136406052 @default.
- W2473772223 cites W2136963578 @default.
- W2473772223 cites W2138270641 @default.
- W2473772223 cites W2138389486 @default.
- W2473772223 cites W2140374231 @default.
- W2473772223 cites W2142203808 @default.
- W2473772223 cites W2142803792 @default.
- W2473772223 cites W2144623340 @default.
- W2473772223 cites W2146659986 @default.
- W2473772223 cites W2150949629 @default.
- W2473772223 cites W2153106128 @default.
- W2473772223 cites W2161301235 @default.
- W2473772223 cites W2164190618 @default.
- W2473772223 cites W2166524215 @default.
- W2473772223 cites W2168956721 @default.
- W2473772223 cites W2176383114 @default.
- W2473772223 cites W2334581933 @default.