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• W2473840711 abstract "Regulator of G-Protein Signaling (RGS) refers to a conserved 120-125 amino acid motif that was first identified by its ability to negatively regulate G-Protein- Coupled Receptor (GPCR) signalling. Mechanistically, RGSs were found to regulate GPCR responses by binding to and stimulating the GTPase activity of the receptor-ac- tivated GTP-bound Gα subunits. There are now over 25 mammalian RGSs containing proteins that are reported to carry out a variety of functions, many of which are unrelated to GPCR signalling. RGS proteins range in size from small proteins that contain little more than an RGS box to very large proteins that contain a variety of domains. The selectivity of function of the RGS proteins is attributable to the divergence of the RGS sequences as well as the presence of a variety of functional motifs, which allow them to interact with other proteins. Here we focus on the RGSs that are involved in modulating GPCR signalling by reviewing the diversity of the mechanisms involved in regulating these RGSs." @default.
• W2473840711 created "2016-07-22" @default.
• W2473840711 creator A5011541246 @default.
• W2473840711 creator A5069201034 @default.
• W2473840711 creator A5074407290 @default.
• W2473840711 date "2006-01-01" @default.
• W2473840711 modified "2023-09-23" @default.
• W2473840711 title "Review Regulatory mechanisms involved in modulating RGS function" @default.
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