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• W2473842640 endingPage "74" @default.
• W2473842640 startingPage "64" @default.
• W2473842640 abstract "Pif1 helicases are a conserved family of eukaryotic proteins involved in the maintenance of both nuclear and mitochondrial DNA. These enzymes possess a number of known and putative functions, which facilitate overall genome integrity. Here we have identified multiple subtypes of Pif1 proteins in various pathogenic and non-pathogenic amoeboid species which possess additional domains not present in other Pif1 helicases. These helicases each possess one of five different accessory domains, which have roles in ubiquitination, origin of DNA replication recognition or single-stranded nucleic acid binding activity. Using a robust phylogenetic approach we examined each Pif1 class, which revealed that gene duplication, fusion and horizontal gene transfer events have all contributed to the evolution of these enzymes. This study has identified the first collection of Pif1 helicases to contain additional domains, which likely confer novel enzymatic activity, or improve existing functionality. Furthermore, the potential functions of these helicases may shed further light on the overall role the Pif1 family plays in genome maintenance." @default.
• W2473842640 created "2016-07-22" @default.
• W2473842640 creator A5062084142 @default.
• W2473842640 creator A5089016271 @default.
• W2473842640 date "2016-10-01" @default.
• W2473842640 modified "2023-09-27" @default.
• W2473842640 title "Identification of Pif1 helicases with novel accessory domains in various amoebae" @default.
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• W2473842640 doi "https://doi.org/10.1016/j.ympev.2016.07.015" @default.
• W2473842640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27421564" @default.
• W2473842640 hasPublicationYear "2016" @default.
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