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- W2473886125 abstract "Objective: To present a practical approach to the diagnosis and management of allergy to beta-lactam antibiotics. Sources: Allergy journals indexed in MEDLINE and LILACS, as well as seminal studies and texts. Summary of the findings: Allergy to penicillin is commonly reported. In many cases, this results in the decision not to use this drug. About 10% of drug allergy reports are confirmed. The clinical manifestations due to allergic reaction to penicillin vary widely, with emphasis on skin disorders. Gell & Coombsi four hypersensitivity mechanisms are involved in allergic reactions. Penicillin is degraded to a major (95%) and minor determinants (5%). Immediate IgE-mediated reactions causing anaphylaxis are associated with minor determinants in 95% of the cases. Hypersensitivity to these products can be assessed using cutaneous tests performed with major and minor determinants, thus avoiding anaphylactic shock in allergic individuals. The present article underscores the basic body of knowledge on allergy to penicillin, providing support for a more accurate diagnosis of this event and for the choice of management in cases of suspected beta-lactam allergy. Conclusions: The incorrect diagnosis of penicillin allergy frequently leads to the exclusion of this drug as a therapeutic option. A better recognition of these situations will enable the use of penicillin and reduce the risks associated with hypersensitivity." @default.
- W2473886125 created "2016-07-22" @default.
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- W2473886125 date "2006-01-01" @default.
- W2473886125 modified "2023-09-27" @default.
- W2473886125 title "Allergy to beta-lactams in pediatrics: a practical approach Alergia a beta-lact‚micos na clÌnica pediÆtrica: uma abordagem prÆtica" @default.
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