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- W2473960983 abstract "Abstract Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to below the limit of detection of clinical assays. However, even with prolonged suppression of viral replication with ART, viremia rebounds rapidly after treatment interruption. Thus, ART is not curative. The principal barrier to cure is a remarkably stable reservoir of latent HIV-1 in resting memory CD4+ T cells. In this review, we consider explanations for the remarkable stability of the latent reservoir. Stability does not appear to reflect replenishment from new infection events but rather normal physiologic processes that provide for immunologic memory. Of particular importance are proliferative processes that drive clonal expansion of infected cells. Recent evidence suggests that in some infected cells, proliferation is a consequence of proviral integration into host genes associated with cell growth. Efforts to cure HIV-1 infection by targeting the latent reservoir may need to consider the potential of latently infected cells to proliferate." @default.
- W2473960983 created "2016-07-22" @default.
- W2473960983 creator A5065092305 @default.
- W2473960983 creator A5072160775 @default.
- W2473960983 creator A5079324608 @default.
- W2473960983 creator A5080830640 @default.
- W2473960983 date "2016-07-15" @default.
- W2473960983 modified "2023-10-12" @default.
- W2473960983 title "The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence" @default.
- W2473960983 cites W1480448067 @default.
- W2473960983 cites W1497870368 @default.
- W2473960983 cites W1505139021 @default.
- W2473960983 cites W1573380982 @default.
- W2473960983 cites W1579654709 @default.
- W2473960983 cites W1586123488 @default.
- W2473960983 cites W1610017743 @default.
- W2473960983 cites W1655510925 @default.
- W2473960983 cites W1857710144 @default.
- W2473960983 cites W1964077677 @default.
- W2473960983 cites W1965019797 @default.
- W2473960983 cites W1965266980 @default.
- W2473960983 cites W1971777539 @default.
- W2473960983 cites W1971931476 @default.
- W2473960983 cites W1972626855 @default.
- W2473960983 cites W1973398091 @default.
- W2473960983 cites W1977189837 @default.
- W2473960983 cites W1977450164 @default.
- W2473960983 cites W1978674283 @default.
- W2473960983 cites W1979531488 @default.
- W2473960983 cites W1980223851 @default.
- W2473960983 cites W1980668957 @default.
- W2473960983 cites W1981440980 @default.
- W2473960983 cites W1981480494 @default.
- W2473960983 cites W1981644527 @default.
- W2473960983 cites W1982434350 @default.
- W2473960983 cites W1983466424 @default.
- W2473960983 cites W1983521453 @default.
- W2473960983 cites W1983919973 @default.
- W2473960983 cites W1987438129 @default.
- W2473960983 cites W1995598331 @default.
- W2473960983 cites W1996183144 @default.
- W2473960983 cites W1996604523 @default.
- W2473960983 cites W1997677784 @default.
- W2473960983 cites W2001375348 @default.
- W2473960983 cites W2003668208 @default.
- W2473960983 cites W2006192795 @default.
- W2473960983 cites W2006597943 @default.
- W2473960983 cites W2006752179 @default.
- W2473960983 cites W2006765654 @default.
- W2473960983 cites W2009695591 @default.
- W2473960983 cites W2009745550 @default.
- W2473960983 cites W2010254493 @default.
- W2473960983 cites W2011208161 @default.
- W2473960983 cites W2011626958 @default.
- W2473960983 cites W2011630381 @default.
- W2473960983 cites W2013711784 @default.
- W2473960983 cites W2016113518 @default.
- W2473960983 cites W2017551575 @default.
- W2473960983 cites W2018359511 @default.
- W2473960983 cites W2019508559 @default.
- W2473960983 cites W2022098233 @default.
- W2473960983 cites W2023255376 @default.
- W2473960983 cites W2023396531 @default.
- W2473960983 cites W2025441671 @default.
- W2473960983 cites W2026547100 @default.
- W2473960983 cites W2029116768 @default.
- W2473960983 cites W2030692398 @default.
- W2473960983 cites W2030844138 @default.
- W2473960983 cites W2030987189 @default.
- W2473960983 cites W2033505817 @default.
- W2473960983 cites W2034160159 @default.
- W2473960983 cites W2039521754 @default.
- W2473960983 cites W2041982728 @default.
- W2473960983 cites W2042498919 @default.
- W2473960983 cites W2043541788 @default.
- W2473960983 cites W2043621278 @default.
- W2473960983 cites W2044273929 @default.
- W2473960983 cites W2045452873 @default.
- W2473960983 cites W2045628835 @default.
- W2473960983 cites W2046159404 @default.
- W2473960983 cites W2047125790 @default.
- W2473960983 cites W2047300635 @default.
- W2473960983 cites W2049653440 @default.
- W2473960983 cites W2051269276 @default.
- W2473960983 cites W2052756867 @default.
- W2473960983 cites W2053021306 @default.
- W2473960983 cites W2053174277 @default.
- W2473960983 cites W2053540546 @default.
- W2473960983 cites W2054437592 @default.
- W2473960983 cites W2056833651 @default.
- W2473960983 cites W2057237578 @default.
- W2473960983 cites W2058268968 @default.
- W2473960983 cites W2058426539 @default.
- W2473960983 cites W2058486365 @default.
- W2473960983 cites W2060829964 @default.
- W2473960983 cites W2060963592 @default.
- W2473960983 cites W2062663311 @default.
- W2473960983 cites W2063950143 @default.