Matches in SemOpenAlex for { <https://semopenalex.org/work/W2473974611> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2473974611 startingPage "2506" @default.
- W2473974611 abstract "The transendothelial transfer of macromolecules has been difficult to study because of the complexities of the in vivo models. We have developed a model of an endothelium cultured on a permeable support and used it to characterize the transendothelial transfer of albumin. Porcine pulmonary artery endothelial cells form a single layer of cells lining the gelatin-impregnated polycarbonate micropore filters, and the cells develop junctional structures similar to endothelial tight junctions observed in vivo. The monolayer resists the flow of electrical current, and the resistance is sensitive to extracellular calcium concentrations. Albumin transfer across the cultured monolayers was found to be asymmetric, and the rate of transfer from interstitium to lumen was greater than that from lumen to interstitium. The asymmetric transfer occurred against a concentration gradient and was abolished by treating the monolayer with NaCN. Increasing albumin concentrations increased the rate of interstitial to luminal transfer, and the process demonstrated saturation at an interstitial albumin concentration of 725 microM. These data point out the usefulness of the in vitro preparation to identify potentially important aspects of transendothelial transport that would be difficult to detect in vivo." @default.
- W2473974611 created "2016-07-22" @default.
- W2473974611 creator A5065564320 @default.
- W2473974611 creator A5068306525 @default.
- W2473974611 date "1987-06-01" @default.
- W2473974611 modified "2023-09-26" @default.
- W2473974611 title "Transendothelial transfer of macromolecules in vitro." @default.
- W2473974611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3297799" @default.
- W2473974611 hasPublicationYear "1987" @default.
- W2473974611 type Work @default.
- W2473974611 sameAs 2473974611 @default.
- W2473974611 citedByCount "9" @default.
- W2473974611 crossrefType "journal-article" @default.
- W2473974611 hasAuthorship W2473974611A5065564320 @default.
- W2473974611 hasAuthorship W2473974611A5068306525 @default.
- W2473974611 hasConcept C12554922 @default.
- W2473974611 hasConcept C134018914 @default.
- W2473974611 hasConcept C150903083 @default.
- W2473974611 hasConcept C185592680 @default.
- W2473974611 hasConcept C202751555 @default.
- W2473974611 hasConcept C204389451 @default.
- W2473974611 hasConcept C207001950 @default.
- W2473974611 hasConcept C2776125364 @default.
- W2473974611 hasConcept C2776992346 @default.
- W2473974611 hasConcept C55493867 @default.
- W2473974611 hasConcept C7070889 @default.
- W2473974611 hasConcept C86803240 @default.
- W2473974611 hasConcept C95444343 @default.
- W2473974611 hasConceptScore W2473974611C12554922 @default.
- W2473974611 hasConceptScore W2473974611C134018914 @default.
- W2473974611 hasConceptScore W2473974611C150903083 @default.
- W2473974611 hasConceptScore W2473974611C185592680 @default.
- W2473974611 hasConceptScore W2473974611C202751555 @default.
- W2473974611 hasConceptScore W2473974611C204389451 @default.
- W2473974611 hasConceptScore W2473974611C207001950 @default.
- W2473974611 hasConceptScore W2473974611C2776125364 @default.
- W2473974611 hasConceptScore W2473974611C2776992346 @default.
- W2473974611 hasConceptScore W2473974611C55493867 @default.
- W2473974611 hasConceptScore W2473974611C7070889 @default.
- W2473974611 hasConceptScore W2473974611C86803240 @default.
- W2473974611 hasConceptScore W2473974611C95444343 @default.
- W2473974611 hasIssue "8" @default.
- W2473974611 hasLocation W24739746111 @default.
- W2473974611 hasOpenAccess W2473974611 @default.
- W2473974611 hasPrimaryLocation W24739746111 @default.
- W2473974611 hasRelatedWork W114232998 @default.
- W2473974611 hasRelatedWork W1776295853 @default.
- W2473974611 hasRelatedWork W1969719203 @default.
- W2473974611 hasRelatedWork W1981463659 @default.
- W2473974611 hasRelatedWork W1981961781 @default.
- W2473974611 hasRelatedWork W2009214271 @default.
- W2473974611 hasRelatedWork W2020719528 @default.
- W2473974611 hasRelatedWork W2027568211 @default.
- W2473974611 hasRelatedWork W2092222240 @default.
- W2473974611 hasRelatedWork W2098950295 @default.
- W2473974611 hasRelatedWork W2105054347 @default.
- W2473974611 hasRelatedWork W2106352950 @default.
- W2473974611 hasRelatedWork W2135189810 @default.
- W2473974611 hasRelatedWork W2153537547 @default.
- W2473974611 hasRelatedWork W2160436707 @default.
- W2473974611 hasRelatedWork W2253732714 @default.
- W2473974611 hasRelatedWork W2396561639 @default.
- W2473974611 hasRelatedWork W2417591744 @default.
- W2473974611 hasRelatedWork W2711531403 @default.
- W2473974611 hasRelatedWork W2431640203 @default.
- W2473974611 hasVolume "46" @default.
- W2473974611 isParatext "false" @default.
- W2473974611 isRetracted "false" @default.
- W2473974611 magId "2473974611" @default.
- W2473974611 workType "article" @default.