FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474073965> ?p ?o ?g. }

• W2474073965 endingPage "41" @default.
• W2474073965 startingPage "933" @default.
• W2474073965 abstract "A hallmark feature of N-methyl-D-aspartate (NMDA) receptors is their voltage-dependent block by extracellular Mg2+. The structural basis for Mg2+ block is not fully understood. Although asparagine residues in the pore-forming M2 regions of NR1 and NR2 subunits influence Mg2+ block, it has been speculated that additional residues are likely to be involved. Here, we report the unexpected finding that a tryptophan residue in the M2 region of NR2 subunits controls Mg2+ block. An NR2B(W607L) mutation abolished block and greatly increased permeation of extracellular Mg2+. A similar effect was seen with a mutation at the equivalent residue in NR2A but not with mutations at the equivalent residue or adjacent residues in NR1. In NR2B, mutations that changed NR2B(W607) to asparagine (W607N) or alanine (W607A) also greatly reduced Mg2+ block, whereas mutations that changed W607 to the aromatic residues tyrosine (W607Y) or phenylalanine (W607F) had little or no effect on Mg2+ block. Furthermore, the W607L, W607N, and W607A mutants, but not the W607Y and W607F mutants, decreased Ba2+ permeability of NMDA channels. Thus, residue NR2B(W607) may be involved in binding of divalent cations, in particular Mg2+, through a cation-pi interaction with the electron-rich aromatic ring of the tryptophan. We previously suggested that NR2B(W607) may contribute to the narrow constriction of the NMDA channel. A model is now proposed in which the M2 loop of NR2B is folded in such a way that NR2B(W607) is positioned at the narrow constriction, at a level similar to NR2B(N616) and NR1(N616), with these three residues forming a binding site for Mg2+." @default.
• W2474073965 created "2016-07-22" @default.
• W2474073965 creator A5018923311 @default.
• W2474073965 creator A5025986770 @default.
• W2474073965 creator A5064666587 @default.
• W2474073965 creator A5064866374 @default.
• W2474073965 creator A5072400842 @default.
• W2474073965 creator A5091483052 @default.
• W2474073965 date "1998-05-01" @default.
• W2474073965 modified "2023-09-23" @default.
• W2474073965 title "The selectivity filter of the N-methyl-D-aspartate receptor: a tryptophan residue controls block and permeation of Mg2+." @default.
• W2474073965 cites W1764357590 @default.
• W2474073965 cites W1898334791 @default.
• W2474073965 cites W1974568825 @default.
• W2474073965 cites W1984528002 @default.
• W2474073965 cites W1990625157 @default.
• W2474073965 cites W1991236701 @default.
• W2474073965 cites W1997568797 @default.
• W2474073965 cites W1998347917 @default.
• W2474073965 cites W2006714198 @default.
• W2474073965 cites W2010503307 @default.
• W2474073965 cites W2031226921 @default.
• W2474073965 cites W2036682782 @default.
• W2474073965 cites W2040720735 @default.
• W2474073965 cites W2040850636 @default.
• W2474073965 cites W2041024256 @default.
• W2474073965 cites W2045302267 @default.
• W2474073965 cites W2053254546 @default.
• W2474073965 cites W2053303814 @default.
• W2474073965 cites W2053980736 @default.
• W2474073965 cites W2059334396 @default.
• W2474073965 cites W2067669919 @default.
• W2474073965 cites W2074340804 @default.
• W2474073965 cites W2074454109 @default.
• W2474073965 cites W2088171173 @default.
• W2474073965 cites W2089338912 @default.
• W2474073965 cites W2090872672 @default.
• W2474073965 cites W2105752803 @default.
• W2474073965 cites W2108765087 @default.
• W2474073965 cites W2110511140 @default.
• W2474073965 cites W2132598806 @default.
• W2474073965 cites W2135437974 @default.
• W2474073965 cites W2148602445 @default.
• W2474073965 cites W2185500017 @default.
• W2474073965 cites W2188496389 @default.
• W2474073965 cites W2336514795 @default.
• W2474073965 cites W2408987925 @default.
• W2474073965 cites W2888511473 @default.
• W2474073965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9584221" @default.
• W2474073965 hasPublicationYear "1998" @default.
• W2474073965 type Work @default.
• W2474073965 sameAs 2474073965 @default.
• W2474073965 citedByCount "31" @default.
• W2474073965 countsByYear W24740739652014 @default.
• W2474073965 countsByYear W24740739652018 @default.
• W2474073965 countsByYear W24740739652019 @default.
• W2474073965 countsByYear W24740739652021 @default.
• W2474073965 countsByYear W24740739652022 @default.
• W2474073965 crossrefType "journal-article" @default.
• W2474073965 hasAuthorship W2474073965A5018923311 @default.
• W2474073965 hasAuthorship W2474073965A5025986770 @default.
• W2474073965 hasAuthorship W2474073965A5064666587 @default.
• W2474073965 hasAuthorship W2474073965A5064866374 @default.
• W2474073965 hasAuthorship W2474073965A5072400842 @default.
• W2474073965 hasAuthorship W2474073965A5091483052 @default.
• W2474073965 hasConcept C104317684 @default.
• W2474073965 hasConcept C11960822 @default.
• W2474073965 hasConcept C12554922 @default.
• W2474073965 hasConcept C143065580 @default.
• W2474073965 hasConcept C170493617 @default.
• W2474073965 hasConcept C185592680 @default.
• W2474073965 hasConcept C2775895851 @default.
• W2474073965 hasConcept C2776165026 @default.
• W2474073965 hasConcept C2776414213 @default.
• W2474073965 hasConcept C2776706248 @default.
• W2474073965 hasConcept C2779856020 @default.
• W2474073965 hasConcept C2781338088 @default.
• W2474073965 hasConcept C515207424 @default.
• W2474073965 hasConcept C55493867 @default.
• W2474073965 hasConcept C67018056 @default.
• W2474073965 hasConcept C71240020 @default.
• W2474073965 hasConcept C86803240 @default.
• W2474073965 hasConceptScore W2474073965C104317684 @default.
• W2474073965 hasConceptScore W2474073965C11960822 @default.
• W2474073965 hasConceptScore W2474073965C12554922 @default.
• W2474073965 hasConceptScore W2474073965C143065580 @default.
• W2474073965 hasConceptScore W2474073965C170493617 @default.
• W2474073965 hasConceptScore W2474073965C185592680 @default.
• W2474073965 hasConceptScore W2474073965C2775895851 @default.
• W2474073965 hasConceptScore W2474073965C2776165026 @default.
• W2474073965 hasConceptScore W2474073965C2776414213 @default.
• W2474073965 hasConceptScore W2474073965C2776706248 @default.
• W2474073965 hasConceptScore W2474073965C2779856020 @default.
• W2474073965 hasConceptScore W2474073965C2781338088 @default.
• W2474073965 hasConceptScore W2474073965C515207424 @default.
• W2474073965 hasConceptScore W2474073965C55493867 @default.
• W2474073965 hasConceptScore W2474073965C67018056 @default.
• W2474073965 hasConceptScore W2474073965C71240020 @default.

• next