Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474080892> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2474080892 endingPage "6" @default.
- W2474080892 startingPage "173" @default.
- W2474080892 abstract "There are many studies in the literature on single drug therapy (monotherapy) for mild to moderate hypertension. These studies show comparable efficacy, side effect profile and compliance. It has not been shown yet, whether the number of patients controlled on monotherapy can be improved by systematically stopping a drug which does not adequately control blood pressure and starting another drug in a sequential manner until blood pressure is well controlled. The aim is to show that sequential drug monotherapy (SDM) is as good as step care therapy (SCT) in controlling mild to moderate hypertension.Patients attending three medical outpatient departments of Christian Medical College and Hospital, with mild to moderate hypertension uncontrolled on single drug therapy formed the patient population. They were then randomised to the sequential drug monotherapy or step care therapy. The choice of one of the five antihypertensive drugs was left to the attending physician.Thirty two and 42 patients entered the study and 28 and 35 completed the study in SCT and SDM group, respectively. Follow up was for a period of three months. BP was controlled 100% each in SCT and SDM groups. Efficacy with intention to treat was 85.2% in SCT and 81.8% in SDM group. Percent controlled with second drug was 82 and 71, controlled with third drug was 18 and 14 in SCT and SDM, respectively. Mean duration of treatment for control for BP was 1.7 and 2.3 months in SCT and SDM groups respectively. Average cost in SCT was Rs 66.28 and in SDM was Rs 45.53 per month (p = 0.005). Incidence of ADR was 28.6% and 10.5% in SCT and SDM groups, respectively (p = 0.06).SDM is as effective as SCT, SDM offers the following advantages: less expensive, better compliance, fewer complications, drug interaction and thus improved quality of life." @default.
- W2474080892 created "2016-07-22" @default.
- W2474080892 creator A5020429270 @default.
- W2474080892 creator A5020662053 @default.
- W2474080892 creator A5047848598 @default.
- W2474080892 creator A5056899922 @default.
- W2474080892 date "1999-02-01" @default.
- W2474080892 modified "2023-09-23" @default.
- W2474080892 title "A randomised control trial on sequential drug monotherapy versus conventional step care therapy in the treatment of mild to moderate hypertension." @default.
- W2474080892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10999082" @default.
- W2474080892 hasPublicationYear "1999" @default.
- W2474080892 type Work @default.
- W2474080892 sameAs 2474080892 @default.
- W2474080892 citedByCount "0" @default.
- W2474080892 crossrefType "journal-article" @default.
- W2474080892 hasAuthorship W2474080892A5020429270 @default.
- W2474080892 hasAuthorship W2474080892A5020662053 @default.
- W2474080892 hasAuthorship W2474080892A5047848598 @default.
- W2474080892 hasAuthorship W2474080892A5056899922 @default.
- W2474080892 hasConcept C126322002 @default.
- W2474080892 hasConcept C140206745 @default.
- W2474080892 hasConcept C168563851 @default.
- W2474080892 hasConcept C2776999253 @default.
- W2474080892 hasConcept C2780035454 @default.
- W2474080892 hasConcept C2780192228 @default.
- W2474080892 hasConcept C2908647359 @default.
- W2474080892 hasConcept C3013748606 @default.
- W2474080892 hasConcept C500440147 @default.
- W2474080892 hasConcept C512399662 @default.
- W2474080892 hasConcept C535046627 @default.
- W2474080892 hasConcept C71924100 @default.
- W2474080892 hasConcept C84393581 @default.
- W2474080892 hasConcept C98274493 @default.
- W2474080892 hasConcept C99454951 @default.
- W2474080892 hasConceptScore W2474080892C126322002 @default.
- W2474080892 hasConceptScore W2474080892C140206745 @default.
- W2474080892 hasConceptScore W2474080892C168563851 @default.
- W2474080892 hasConceptScore W2474080892C2776999253 @default.
- W2474080892 hasConceptScore W2474080892C2780035454 @default.
- W2474080892 hasConceptScore W2474080892C2780192228 @default.
- W2474080892 hasConceptScore W2474080892C2908647359 @default.
- W2474080892 hasConceptScore W2474080892C3013748606 @default.
- W2474080892 hasConceptScore W2474080892C500440147 @default.
- W2474080892 hasConceptScore W2474080892C512399662 @default.
- W2474080892 hasConceptScore W2474080892C535046627 @default.
- W2474080892 hasConceptScore W2474080892C71924100 @default.
- W2474080892 hasConceptScore W2474080892C84393581 @default.
- W2474080892 hasConceptScore W2474080892C98274493 @default.
- W2474080892 hasConceptScore W2474080892C99454951 @default.
- W2474080892 hasIssue "2" @default.
- W2474080892 hasLocation W24740808921 @default.
- W2474080892 hasOpenAccess W2474080892 @default.
- W2474080892 hasPrimaryLocation W24740808921 @default.
- W2474080892 hasRelatedWork W2042732374 @default.
- W2474080892 hasRelatedWork W2048757290 @default.
- W2474080892 hasRelatedWork W2050174578 @default.
- W2474080892 hasRelatedWork W2098758482 @default.
- W2474080892 hasRelatedWork W2364520870 @default.
- W2474080892 hasRelatedWork W2376921751 @default.
- W2474080892 hasRelatedWork W2395552301 @default.
- W2474080892 hasRelatedWork W2473027819 @default.
- W2474080892 hasRelatedWork W2141091961 @default.
- W2474080892 hasRelatedWork W2292600241 @default.
- W2474080892 hasVolume "47" @default.
- W2474080892 isParatext "false" @default.
- W2474080892 isRetracted "false" @default.
- W2474080892 magId "2474080892" @default.
- W2474080892 workType "article" @default.