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- W2474114920 abstract "In frontal brainstem slices of Wistar rats, the whole-cell patch-clamp recordings showed the effect of opioid peptide leu-enkephalin (10 nM-1 microM) on membrane potential and spontaneous activity pattern of neurons in two divisions of the respiratory center, ventro-lateral area of the solitary tract nucleus, and the pre-Botzinger complex. Leu-enkephalin induced a membrane hyperpolarization of the respiratory centre neurons and reduction of the spike activity level in spontaneously active units. After administration of leu-enkephalin, a decrease in frequency of bursts was found in bursting cells of the pro-Botzinger complex; in two cases, there was a transition of bursting activity to tonic one. The data suggest that the mechanism of the central respiratory activity of leu-enkephalin is based on its direct action at the level of membrane of the respiratory centre neurons." @default.
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- W2474114920 date "2005-06-01" @default.
- W2474114920 modified "2023-09-28" @default.
- W2474114920 title "[The effect of leu-enkephalin on membrane potential and activity of the rat respiratory center neurons in vitro]." @default.
- W2474114920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16119445" @default.
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