Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474118470> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2474118470 endingPage "397" @default.
- W2474118470 startingPage "394" @default.
- W2474118470 abstract "The aims of this study were to examine the effects of KB-R7943, an inhibitor of Na(+)/Ca(2+) exchanger, on the endothelium-dependent relaxation (EDR) in diabetic rat aorta. Both acetylcholine (ACh)-induced EDR and sodium nitroprusside (SNP)-induced endothelium-independent relaxation (EIR) were measured in aortic rings of nondiabetic and streptozotocin-diabetic rats. Diabetes mellitus was induced by single injection of streptozotocin (60 mg/kg). The treated rats received 0.01 or 0.1 mg/kg/day of KB-R7943 for 8 weeks. ACh-induced relaxation was impaired in diabetic compared to control rings and the vasodilatation to SNP was unaffected. Treatment with KB-R7943 markedly enhanced relaxation to ACh in diabetic but not in control rings. KB-R7943 significantly increased superoxide dismutase (SOD) activity and the nitric oxide (NO) release. These results suggest that KB-R7943 can restore impaired EDR in aortic rings of diabetic rats, which may be related to scavenging oxygen free radicals and enhancing NO production." @default.
- W2474118470 created "2016-07-22" @default.
- W2474118470 creator A5003949397 @default.
- W2474118470 creator A5025317539 @default.
- W2474118470 creator A5043274921 @default.
- W2474118470 creator A5068855097 @default.
- W2474118470 date "2015-04-21" @default.
- W2474118470 modified "2023-10-16" @default.
- W2474118470 title "Na+/Ca2+ Exchanger Inhibitor Restores Endothelium-dependent Relaxation in Diabetic Rat Aorta" @default.
- W2474118470 doi "https://doi.org/10.1055/s-0035-1548928" @default.
- W2474118470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25962405" @default.
- W2474118470 hasPublicationYear "2015" @default.
- W2474118470 type Work @default.
- W2474118470 sameAs 2474118470 @default.
- W2474118470 citedByCount "1" @default.
- W2474118470 countsByYear W24741184702016 @default.
- W2474118470 crossrefType "journal-article" @default.
- W2474118470 hasAuthorship W2474118470A5003949397 @default.
- W2474118470 hasAuthorship W2474118470A5025317539 @default.
- W2474118470 hasAuthorship W2474118470A5043274921 @default.
- W2474118470 hasAuthorship W2474118470A5068855097 @default.
- W2474118470 hasConcept C114574056 @default.
- W2474118470 hasConcept C120770815 @default.
- W2474118470 hasConcept C126322002 @default.
- W2474118470 hasConcept C134018914 @default.
- W2474118470 hasConcept C178790620 @default.
- W2474118470 hasConcept C185592680 @default.
- W2474118470 hasConcept C2775838275 @default.
- W2474118470 hasConcept C2775910092 @default.
- W2474118470 hasConcept C2776029896 @default.
- W2474118470 hasConcept C2776151105 @default.
- W2474118470 hasConcept C2776992346 @default.
- W2474118470 hasConcept C2779280383 @default.
- W2474118470 hasConcept C2779610285 @default.
- W2474118470 hasConcept C2779980429 @default.
- W2474118470 hasConcept C2780972559 @default.
- W2474118470 hasConcept C519581460 @default.
- W2474118470 hasConcept C537181965 @default.
- W2474118470 hasConcept C555293320 @default.
- W2474118470 hasConcept C71924100 @default.
- W2474118470 hasConceptScore W2474118470C114574056 @default.
- W2474118470 hasConceptScore W2474118470C120770815 @default.
- W2474118470 hasConceptScore W2474118470C126322002 @default.
- W2474118470 hasConceptScore W2474118470C134018914 @default.
- W2474118470 hasConceptScore W2474118470C178790620 @default.
- W2474118470 hasConceptScore W2474118470C185592680 @default.
- W2474118470 hasConceptScore W2474118470C2775838275 @default.
- W2474118470 hasConceptScore W2474118470C2775910092 @default.
- W2474118470 hasConceptScore W2474118470C2776029896 @default.
- W2474118470 hasConceptScore W2474118470C2776151105 @default.
- W2474118470 hasConceptScore W2474118470C2776992346 @default.
- W2474118470 hasConceptScore W2474118470C2779280383 @default.
- W2474118470 hasConceptScore W2474118470C2779610285 @default.
- W2474118470 hasConceptScore W2474118470C2779980429 @default.
- W2474118470 hasConceptScore W2474118470C2780972559 @default.
- W2474118470 hasConceptScore W2474118470C519581460 @default.
- W2474118470 hasConceptScore W2474118470C537181965 @default.
- W2474118470 hasConceptScore W2474118470C555293320 @default.
- W2474118470 hasConceptScore W2474118470C71924100 @default.
- W2474118470 hasIssue "07" @default.
- W2474118470 hasLocation W24741184701 @default.
- W2474118470 hasLocation W24741184702 @default.
- W2474118470 hasOpenAccess W2474118470 @default.
- W2474118470 hasPrimaryLocation W24741184701 @default.
- W2474118470 hasRelatedWork W1979055340 @default.
- W2474118470 hasRelatedWork W2021947224 @default.
- W2474118470 hasRelatedWork W2040354067 @default.
- W2474118470 hasRelatedWork W2132019871 @default.
- W2474118470 hasRelatedWork W2362812864 @default.
- W2474118470 hasRelatedWork W2379293345 @default.
- W2474118470 hasRelatedWork W2422938348 @default.
- W2474118470 hasRelatedWork W2433942823 @default.
- W2474118470 hasRelatedWork W2738423454 @default.
- W2474118470 hasRelatedWork W3144898162 @default.
- W2474118470 hasVolume "123" @default.
- W2474118470 isParatext "false" @default.
- W2474118470 isRetracted "false" @default.
- W2474118470 magId "2474118470" @default.
- W2474118470 workType "article" @default.