FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474202904> ?p ?o ?g. }

• W2474202904 endingPage "e1005747" @default.
• W2474202904 startingPage "e1005747" @default.
• W2474202904 abstract "Human papillomaviruses (HPVs) are epithelial tropic viruses that link their productive life cycles to the differentiation of infected host keratinocytes. A subset of the over 200 HPV types, referred to as high-risk, are the causative agents of most anogenital malignancies. HPVs infect cells in the basal layer, but restrict viral genome amplification, late gene expression, and capsid assembly to highly differentiated cells that are active in the cell cycle. In this study, we demonstrate that HPV proteins regulate the expression and activities of a critical cellular transcription factor, KLF4, through post-transcriptional and post-translational mechanisms. Our studies show that KLF4 regulates differentiation as well as cell cycle progression, and binds to sequences in the upstream regulatory region (URR) to regulate viral transcription in cooperation with Blimp1. KLF4 levels are increased in HPV-positive cells through a post-transcriptional mechanism involving E7-mediated suppression of cellular miR-145, as well as at the post-translational level by E6-directed inhibition of its sumoylation and phosphorylation. The alterations in KLF4 levels and functions results in activation and suppression of a subset of KLF4 target genes, including TCHHL1, VIM, ACTN1, and POT1, that is distinct from that seen in normal keratinocytes. Knockdown of KLF4 with shRNAs in cells that maintain HPV episomes blocked genome amplification and abolished late gene expression upon differentiation. While KLF4 is indispensable for the proliferation and differentiation of normal keratinocytes, it is necessary only for differentiation-associated functions of HPV-positive keratinocytes. Increases in KLF4 levels alone do not appear to be sufficient to explain the effects on proliferation and differentiation of HPV-positive cells indicating that additional modifications are important. KLF4 has also been shown to be a critical regulator of lytic Epstein Barr virus (EBV) replication underscoring the importance of this cellular transcription factor in the life cycles of multiple human cancer viruses." @default.
• W2474202904 created "2016-07-22" @default.
• W2474202904 creator A5006838633 @default.
• W2474202904 creator A5007196678 @default.
• W2474202904 creator A5024814904 @default.
• W2474202904 creator A5086711331 @default.
• W2474202904 date "2016-07-07" @default.
• W2474202904 modified "2023-10-11" @default.
• W2474202904 title "Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle" @default.
• W2474202904 cites W1266602514 @default.
• W2474202904 cites W1513329088 @default.
• W2474202904 cites W1539426772 @default.
• W2474202904 cites W1562069246 @default.
• W2474202904 cites W1607774948 @default.
• W2474202904 cites W1685493687 @default.
• W2474202904 cites W1801314933 @default.
• W2474202904 cites W1830126998 @default.
• W2474202904 cites W1895791018 @default.
• W2474202904 cites W1938968123 @default.
• W2474202904 cites W1949487930 @default.
• W2474202904 cites W1964686684 @default.
• W2474202904 cites W1979933285 @default.
• W2474202904 cites W1982202785 @default.
• W2474202904 cites W1983110775 @default.
• W2474202904 cites W1990657900 @default.
• W2474202904 cites W1996986490 @default.
• W2474202904 cites W2003098088 @default.
• W2474202904 cites W2005326726 @default.
• W2474202904 cites W2005356516 @default.
• W2474202904 cites W2005782583 @default.
• W2474202904 cites W2010867904 @default.
• W2474202904 cites W2020772572 @default.
• W2474202904 cites W2022910618 @default.
• W2474202904 cites W2025161791 @default.
• W2474202904 cites W2025320368 @default.
• W2474202904 cites W2026299035 @default.
• W2474202904 cites W2028349099 @default.
• W2474202904 cites W2033159340 @default.
• W2474202904 cites W2037678482 @default.
• W2474202904 cites W2038479484 @default.
• W2474202904 cites W2048295632 @default.
• W2474202904 cites W2048559665 @default.
• W2474202904 cites W2056373000 @default.
• W2474202904 cites W2060123496 @default.
• W2474202904 cites W2061862766 @default.
• W2474202904 cites W2065853108 @default.
• W2474202904 cites W2066332001 @default.
• W2474202904 cites W2070770055 @default.
• W2474202904 cites W2070964166 @default.
• W2474202904 cites W2073396586 @default.
• W2474202904 cites W2080943769 @default.
• W2474202904 cites W2090130596 @default.
• W2474202904 cites W2091776694 @default.
• W2474202904 cites W2094469725 @default.
• W2474202904 cites W2109560748 @default.
• W2474202904 cites W2112833365 @default.
• W2474202904 cites W2117213405 @default.
• W2474202904 cites W2125987139 @default.
• W2474202904 cites W2137192946 @default.
• W2474202904 cites W2137586531 @default.
• W2474202904 cites W2138207763 @default.
• W2474202904 cites W2138977668 @default.
• W2474202904 cites W2140687712 @default.
• W2474202904 cites W2140729960 @default.
• W2474202904 cites W2141458291 @default.
• W2474202904 cites W2147725019 @default.
• W2474202904 cites W2148511982 @default.
• W2474202904 cites W2153503700 @default.
• W2474202904 cites W2157930304 @default.
• W2474202904 cites W2158934478 @default.
• W2474202904 cites W2161325043 @default.
• W2474202904 cites W2161581661 @default.
• W2474202904 cites W2164470499 @default.
• W2474202904 cites W2168045714 @default.
• W2474202904 cites W2169675742 @default.
• W2474202904 cites W2221626926 @default.
• W2474202904 cites W2417018853 @default.
• W2474202904 doi "https://doi.org/10.1371/journal.ppat.1005747" @default.
• W2474202904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4936677" @default.
• W2474202904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27386862" @default.
• W2474202904 hasPublicationYear "2016" @default.
• W2474202904 type Work @default.
• W2474202904 sameAs 2474202904 @default.
• W2474202904 citedByCount "28" @default.
• W2474202904 countsByYear W24742029042017 @default.
• W2474202904 countsByYear W24742029042018 @default.
• W2474202904 countsByYear W24742029042019 @default.
• W2474202904 countsByYear W24742029042020 @default.
• W2474202904 countsByYear W24742029042021 @default.
• W2474202904 countsByYear W24742029042022 @default.
• W2474202904 countsByYear W24742029042023 @default.
• W2474202904 crossrefType "journal-article" @default.
• W2474202904 hasAuthorship W2474202904A5006838633 @default.
• W2474202904 hasAuthorship W2474202904A5007196678 @default.
• W2474202904 hasAuthorship W2474202904A5024814904 @default.
• W2474202904 hasAuthorship W2474202904A5086711331 @default.
• W2474202904 hasBestOaLocation W24742029041 @default.
• W2474202904 hasConcept C104317684 @default.

• next