FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474217260> ?p ?o ?g. }

• W2474217260 endingPage "895" @default.
• W2474217260 startingPage "888" @default.
• W2474217260 abstract "Posttraumatic stress disorder (PTSD) is an independent risk factor for cardiovascular diseases. This study investigated the molecular mechanisms underlying myocardial injury induced by simulated PTSD.Sprague-Dawley rats were randomly divided into two groups: control group (n = 18) and PTSD group (n = 30). The PTSD model was replicated using the single prolonged stress (SPS) method. On the 14th day poststress, the apoptotic cells in myocardium were assessed using both TUNEL method and transmission electron microscopy; the protein levels of the endoplasmic reticulum stress (ERS) molecules were measured by using Western blotting analysis.Exposure to SPS resulted in characteristic morphologic changes of apoptosis in cardiomyocytes assessed by transmission electron microscopy. Moreover, TUNEL staining was also indicative of the elevated apoptosis rate of cardiomyocytes from the SPS rats (30.69% versus 7.26%, p < .001). Simulated PTSD also induced ERS in myocardium, demonstrated by up-regulation of protein levels of glucose-regulated protein 78 (0.64 versus 0.26, p = .017), calreticulin (p = .040), and CCAAT/enhancer-binding protein-homologous protein (0.95 versus 0.43, p = .047), phosphorylation of protein kinase RNA-like ER kinase (p = .003), and caspase 12 activation (0.30 versus 0.06, p < .001) in myocardium from the SPS rats. The ratio of Bcl-2 to Bax decreased significantly in myocardium from the SPS rats (p = .005).The ERS-related apoptosis mediated by the protein kinase RNA-like ER kinase/CCAAT/enhancer-binding protein-homologous protein and caspase 12 pathways may be associated with myocardial injury in a rat model simulating PTSD. This study may advance our understanding of how PTSD contributes to myocardial injury on a molecular level." @default.
• W2474217260 created "2016-07-22" @default.
• W2474217260 creator A5003244163 @default.
• W2474217260 creator A5009408901 @default.
• W2474217260 creator A5012304212 @default.
• W2474217260 creator A5027840563 @default.
• W2474217260 creator A5059492103 @default.
• W2474217260 creator A5071068810 @default.
• W2474217260 creator A5089556373 @default.
• W2474217260 creator A5090913127 @default.
• W2474217260 date "2016-10-01" @default.
• W2474217260 modified "2023-09-26" @default.
• W2474217260 title "Molecular Mechanisms of Stress-Induced Myocardial Injury in a Rat Model Simulating Posttraumatic Stress Disorder" @default.
• W2474217260 cites W1562554724 @default.
• W2474217260 cites W159617335 @default.
• W2474217260 cites W1905806846 @default.
• W2474217260 cites W1964361812 @default.
• W2474217260 cites W1967992419 @default.
• W2474217260 cites W1979807766 @default.
• W2474217260 cites W1986189365 @default.
• W2474217260 cites W1989618975 @default.
• W2474217260 cites W1989811349 @default.
• W2474217260 cites W2013835629 @default.
• W2474217260 cites W2018561106 @default.
• W2474217260 cites W2022334783 @default.
• W2474217260 cites W2024475665 @default.
• W2474217260 cites W2025511820 @default.
• W2474217260 cites W2031484011 @default.
• W2474217260 cites W2036772741 @default.
• W2474217260 cites W2039047753 @default.
• W2474217260 cites W2055645746 @default.
• W2474217260 cites W2066062893 @default.
• W2474217260 cites W2067285181 @default.
• W2474217260 cites W2067701929 @default.
• W2474217260 cites W2073471683 @default.
• W2474217260 cites W2074587311 @default.
• W2474217260 cites W2078010040 @default.
• W2474217260 cites W2094355167 @default.
• W2474217260 cites W2102193810 @default.
• W2474217260 cites W2105194498 @default.
• W2474217260 cites W2109229232 @default.
• W2474217260 cites W2115308595 @default.
• W2474217260 cites W2117585370 @default.
• W2474217260 cites W2122103893 @default.
• W2474217260 cites W2139825658 @default.
• W2474217260 cites W2149257689 @default.
• W2474217260 cites W2151002840 @default.
• W2474217260 cites W2156152261 @default.
• W2474217260 cites W2187671036 @default.
• W2474217260 cites W2192080449 @default.
• W2474217260 cites W2315395338 @default.
• W2474217260 cites W2389293454 @default.
• W2474217260 cites W60084911 @default.
• W2474217260 doi "https://doi.org/10.1097/psy.0000000000000353" @default.
• W2474217260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5051518" @default.
• W2474217260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27359173" @default.
• W2474217260 hasPublicationYear "2016" @default.
• W2474217260 type Work @default.
• W2474217260 sameAs 2474217260 @default.
• W2474217260 citedByCount "8" @default.
• W2474217260 countsByYear W24742172602018 @default.
• W2474217260 countsByYear W24742172602019 @default.
• W2474217260 countsByYear W24742172602020 @default.
• W2474217260 countsByYear W24742172602021 @default.
• W2474217260 crossrefType "journal-article" @default.
• W2474217260 hasAuthorship W2474217260A5003244163 @default.
• W2474217260 hasAuthorship W2474217260A5009408901 @default.
• W2474217260 hasAuthorship W2474217260A5012304212 @default.
• W2474217260 hasAuthorship W2474217260A5027840563 @default.
• W2474217260 hasAuthorship W2474217260A5059492103 @default.
• W2474217260 hasAuthorship W2474217260A5071068810 @default.
• W2474217260 hasAuthorship W2474217260A5089556373 @default.
• W2474217260 hasAuthorship W2474217260A5090913127 @default.
• W2474217260 hasBestOaLocation W24742172602 @default.
• W2474217260 hasConcept C104317684 @default.
• W2474217260 hasConcept C126322002 @default.
• W2474217260 hasConcept C134018914 @default.
• W2474217260 hasConcept C139447449 @default.
• W2474217260 hasConcept C153911025 @default.
• W2474217260 hasConcept C158617107 @default.
• W2474217260 hasConcept C16685009 @default.
• W2474217260 hasConcept C184235292 @default.
• W2474217260 hasConcept C185592680 @default.
• W2474217260 hasConcept C190283241 @default.
• W2474217260 hasConcept C196795494 @default.
• W2474217260 hasConcept C2780292996 @default.
• W2474217260 hasConcept C31573885 @default.
• W2474217260 hasConcept C55493867 @default.
• W2474217260 hasConcept C71924100 @default.
• W2474217260 hasConcept C85265743 @default.
• W2474217260 hasConcept C86803240 @default.
• W2474217260 hasConcept C95444343 @default.
• W2474217260 hasConcept C97029542 @default.
• W2474217260 hasConcept C98424977 @default.
• W2474217260 hasConceptScore W2474217260C104317684 @default.
• W2474217260 hasConceptScore W2474217260C126322002 @default.
• W2474217260 hasConceptScore W2474217260C134018914 @default.
• W2474217260 hasConceptScore W2474217260C139447449 @default.

• next