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- W24742253 abstract "Background and objective CCR7 is closely related with the lymph node metastasis of non-small cell lung cancer. The objective of this work is to investigate the expressions of chemokine receptor CCR7, hypoxia inducible factor 1? (HIF-1?) and hypoxia inducible factor 2? (HIF-2?) protein in non small cell lung cancer and the relationships of their expression, and to study the mechanism of CCR7 upregulation in NSCLC. Methods T he levels of expressions of CCR7, HIF-1? and HIF-2? protein were detected in 94 specimens of human primary non small cell lung cancer by immunohistochemical S-P method. Human lung adenocarcinoma cell line A549 cells were transfected by lipofection with HIF-1? siRNA?HIF-2? siRNA, the change of CCR7 was observed by RT-PCR and immunofluorescence staining. Correlations between the expression of CCR7 and HIF-1?, HIF-2? were respectively analyzed. Results Immunohistochemistry showed that CCR7 was distributed in cytoplasm and/or membrane of tumor cells, HIF-1?, HIF-2? was distributed in nucleus and/or cytoplasm of tumor cells. The levels of expressions of CCR7, HIF-1? and HIF-2? protein were found to be 75.53% (71/94), 54.25% (51/ 94) and 70.21% (66/94) in non small cell lung cancer, respectively. the levels of expression of CCR7 protein were closely related to the clinical stages (P 0.05). Furthermore, A significant correlation were found among CCR7, Hif-1? and HIF-2? (r =0.272, P <0.01) (r=0.225, P <0.05). In addition, the expression of CCR7 mRNA and protein levels were decreased in the transfected specificHIF-1?, HIF-2?siRNA group (P <0.05). Conclusion CCR7 expression is significantly associated with non small celllung cancer invasion and metastasis. The upregulation of CCR7 is regulated by HIF-1? and HIF-2? in non small celllung cancer." @default.
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- W24742253 date "2008-10-20" @default.
- W24742253 modified "2023-09-27" @default.
- W24742253 title "[Upregulation of the Chemokine Receptor CCR7 expression by HIF-1alpha and HIF-2alpha in non-small cell lung cancer.]." @default.
- W24742253 doi "https://doi.org/10.3779/j.issn.1009-3419.2008.05.024" @default.
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