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- W2474258899 abstract "Introduction. With the large-scale use of antiretroviral combination therapy in patients with HIV / AIDS, we have observed an increased frequency of chronic and degenerative diseases such as chronic renal failure in this population. Some drugs used, such as tenofovir, as well as lesions attributed to infection itself, are potentially nephrotoxic. Goals. This study aims to evaluate the prevalence and factors associated with kidney abnormalities in patients with HIV / AIDS treated at a reference service in Teresina, Piaui. Materials and methods. One cross-sectional study was conducted in patients with HIV / AIDS treated at the outpatient clinic of the Institute of Tropical Diseases Natan Portella. We calculated a random sample of 109 subjects, considering an expected frequency of kidney abnormalities of 5%, 4% error and reliability level of 95% .The data collection took place from March to July 2015. In addition to routine tests, more specific and sensitive tests were performed in order to assess the renal function: isolated microalbuminuria in urine, 03B22 microglobulin in urine and serum phosphorusResults. We observed that 9.2% of patients had renal dysfunction with eGFR 60 years (58.3%) and the use of tenofovir (39.4%). Patients with eGFR <60 ml/min/1.73m² and hypertensive and diabetic patients had a longer usage of ART. There was no correlation between CD4 lymphocyte count and glomerular filtration rate. Conclusions. Markers as microalbuminuria isolated in urine and 03B22-microglobulin in urine are relevance to the early identification of patients with incipient renal dysfunction. Early diagnosis of renal disease in patients with HIV and identification of risk factors is critical to prevent the progression of kidney damage and to the institution of the appropriate treatment" @default.
- W2474258899 created "2016-07-22" @default.
- W2474258899 creator A5051794200 @default.
- W2474258899 date "2015-01-01" @default.
- W2474258899 modified "2023-09-27" @default.
- W2474258899 title "Prevalência e Fatores Associados à Disfunção Renal em Pacientes com HIV/AIDS" @default.
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