Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474277834> ?p ?o ?g. }
- W2474277834 endingPage "1853" @default.
- W2474277834 startingPage "1843" @default.
- W2474277834 abstract "Circadian rhythms are deeply rooted in the biology of virtually all organisms. The pervasive use of artificial lighting in modern society disrupts circadian rhythms and can be detrimental to our health. To investigate the relationship between disrupting circadian rhythmicity and disease, we exposed mice to continuous light (LL) for 24 weeks and measured several major health parameters. Long-term neuronal recordings revealed that 24 weeks of LL reduced rhythmicity in the central circadian pacemaker of the suprachiasmatic nucleus (SCN) by 70%. Strikingly, LL exposure also reduced skeletal muscle function (forelimb grip strength, wire hanging duration, and grid hanging duration), caused trabecular bone deterioration, and induced a transient pro-inflammatory state. After the mice were returned to a standard light-dark cycle, the SCN neurons rapidly recovered their normal high-amplitude rhythm, and the aforementioned health parameters returned to normal. These findings strongly suggest that a disrupted circadian rhythm reversibly induces detrimental effects on multiple biological processes." @default.
- W2474277834 created "2016-07-22" @default.
- W2474277834 creator A5000644268 @default.
- W2474277834 creator A5001523779 @default.
- W2474277834 creator A5025693848 @default.
- W2474277834 creator A5026451087 @default.
- W2474277834 creator A5027755679 @default.
- W2474277834 creator A5030112404 @default.
- W2474277834 creator A5032252700 @default.
- W2474277834 creator A5033643112 @default.
- W2474277834 creator A5041667067 @default.
- W2474277834 creator A5044337748 @default.
- W2474277834 creator A5044804798 @default.
- W2474277834 creator A5052198457 @default.
- W2474277834 creator A5056851220 @default.
- W2474277834 creator A5059863727 @default.
- W2474277834 creator A5066128766 @default.
- W2474277834 date "2016-07-01" @default.
- W2474277834 modified "2023-10-15" @default.
- W2474277834 title "Environmental 24-hr Cycles Are Essential for Health" @default.
- W2474277834 cites W127337627 @default.
- W2474277834 cites W1482178272 @default.
- W2474277834 cites W1492824519 @default.
- W2474277834 cites W1534458874 @default.
- W2474277834 cites W1605337130 @default.
- W2474277834 cites W1659693438 @default.
- W2474277834 cites W1968877294 @default.
- W2474277834 cites W1975482601 @default.
- W2474277834 cites W1977711623 @default.
- W2474277834 cites W1980975002 @default.
- W2474277834 cites W1981528580 @default.
- W2474277834 cites W1982379219 @default.
- W2474277834 cites W1984392358 @default.
- W2474277834 cites W1988727379 @default.
- W2474277834 cites W1990356805 @default.
- W2474277834 cites W1991944917 @default.
- W2474277834 cites W1994343513 @default.
- W2474277834 cites W1997364930 @default.
- W2474277834 cites W2027058093 @default.
- W2474277834 cites W2027362159 @default.
- W2474277834 cites W2027396069 @default.
- W2474277834 cites W2028063963 @default.
- W2474277834 cites W2030772730 @default.
- W2474277834 cites W2031071294 @default.
- W2474277834 cites W2039334551 @default.
- W2474277834 cites W2046088341 @default.
- W2474277834 cites W2048232312 @default.
- W2474277834 cites W2049317326 @default.
- W2474277834 cites W2052133049 @default.
- W2474277834 cites W2052303540 @default.
- W2474277834 cites W2053866174 @default.
- W2474277834 cites W2057737927 @default.
- W2474277834 cites W2064057421 @default.
- W2474277834 cites W2070187507 @default.
- W2474277834 cites W2071360237 @default.
- W2474277834 cites W2080024848 @default.
- W2474277834 cites W2082409982 @default.
- W2474277834 cites W2082837340 @default.
- W2474277834 cites W2094874423 @default.
- W2474277834 cites W2098095516 @default.
- W2474277834 cites W2106339147 @default.
- W2474277834 cites W2106997306 @default.
- W2474277834 cites W2108988707 @default.
- W2474277834 cites W2111785699 @default.
- W2474277834 cites W2115475091 @default.
- W2474277834 cites W2117764631 @default.
- W2474277834 cites W2122753291 @default.
- W2474277834 cites W2128261237 @default.
- W2474277834 cites W2133430418 @default.
- W2474277834 cites W2135165577 @default.
- W2474277834 cites W2135374462 @default.
- W2474277834 cites W2136163260 @default.
- W2474277834 cites W2136342516 @default.
- W2474277834 cites W2140832481 @default.
- W2474277834 cites W2146233711 @default.
- W2474277834 cites W2148780014 @default.
- W2474277834 cites W2152065905 @default.
- W2474277834 cites W2156204070 @default.
- W2474277834 cites W2157778907 @default.
- W2474277834 cites W2410855834 @default.
- W2474277834 cites W3101738525 @default.
- W2474277834 doi "https://doi.org/10.1016/j.cub.2016.05.038" @default.
- W2474277834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27426518" @default.
- W2474277834 hasPublicationYear "2016" @default.
- W2474277834 type Work @default.
- W2474277834 sameAs 2474277834 @default.
- W2474277834 citedByCount "98" @default.
- W2474277834 countsByYear W24742778342016 @default.
- W2474277834 countsByYear W24742778342017 @default.
- W2474277834 countsByYear W24742778342018 @default.
- W2474277834 countsByYear W24742778342019 @default.
- W2474277834 countsByYear W24742778342020 @default.
- W2474277834 countsByYear W24742778342021 @default.
- W2474277834 countsByYear W24742778342022 @default.
- W2474277834 countsByYear W24742778342023 @default.
- W2474277834 crossrefType "journal-article" @default.
- W2474277834 hasAuthorship W2474277834A5000644268 @default.
- W2474277834 hasAuthorship W2474277834A5001523779 @default.