FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474289722> ?p ?o ?g. }

• W2474289722 endingPage "6389" @default.
• W2474289722 startingPage "6379" @default.
• W2474289722 abstract "A major obstacle confronting the discovery and development of new antibacterial agents to combat resistant Gram-negative (GN) organisms is the lack of a rational process for endowing compounds with properties that allow (or promote) entry into the bacterial cytoplasm. The major permeability difference between GN and Gram-positive (GP) bacteria is the GN outer membrane (OM) which is a permeability barrier itself and potentiates efflux pumps that expel compounds. Based on the fact that OM-permeable and efflux-deleted GNs are sensitive to many anti-GP drugs, recent efforts to approach the GN entry problem have focused on ways of avoiding efflux and transiting or compromising the OM, with the tacit assumption that this could allow entry of compounds into the GN cytoplasm. But bypassing the OM and efflux obstacles does not take into account the additional requirement of penetrating the cytoplasmic membrane (CM) whose sieving properties appear to be orthogonal to that of the OM. That is, tailoring compounds to transit the OM may well compromise their ability to enter the cytoplasm. Thus, a Gestalt approach to understanding the chemical requirements for GN entry seems a useful adjunct. This might consist of characterizing compounds which reach the cytoplasm, grouping (or binning) by routes of entry and formulating chemical ‘rules’ for those bins. This will require acquisition of data on large numbers of compounds, using non-activity-dependent methods of measuring accumulation in the cytoplasm." @default.
• W2474289722 created "2016-07-22" @default.
• W2474289722 creator A5044124954 @default.
• W2474289722 date "2016-12-01" @default.
• W2474289722 modified "2023-09-30" @default.
• W2474289722 title "A Gestalt approach to Gram-negative entry" @default.
• W2474289722 cites W1543263357 @default.
• W2474289722 cites W1557633902 @default.
• W2474289722 cites W1573080626 @default.
• W2474289722 cites W1601951089 @default.
• W2474289722 cites W1626958299 @default.
• W2474289722 cites W1785018154 @default.
• W2474289722 cites W183722190 @default.
• W2474289722 cites W1853559395 @default.
• W2474289722 cites W1909542718 @default.
• W2474289722 cites W1964141703 @default.
• W2474289722 cites W1964482783 @default.
• W2474289722 cites W1971221730 @default.
• W2474289722 cites W1972271331 @default.
• W2474289722 cites W1974072532 @default.
• W2474289722 cites W1975361143 @default.
• W2474289722 cites W1978757285 @default.
• W2474289722 cites W1982278009 @default.
• W2474289722 cites W1989889086 @default.
• W2474289722 cites W1993936359 @default.
• W2474289722 cites W1996701239 @default.
• W2474289722 cites W1998357541 @default.
• W2474289722 cites W1999979510 @default.
• W2474289722 cites W2000640630 @default.
• W2474289722 cites W2001166652 @default.
• W2474289722 cites W2010598074 @default.
• W2474289722 cites W2011347701 @default.
• W2474289722 cites W2011602346 @default.
• W2474289722 cites W2016666824 @default.
• W2474289722 cites W2018300362 @default.
• W2474289722 cites W2019509230 @default.
• W2474289722 cites W2020708627 @default.
• W2474289722 cites W2027432781 @default.
• W2474289722 cites W2031576029 @default.
• W2474289722 cites W2032764052 @default.
• W2474289722 cites W2035474027 @default.
• W2474289722 cites W2036716477 @default.
• W2474289722 cites W2037001581 @default.
• W2474289722 cites W2037184494 @default.
• W2474289722 cites W2038684541 @default.
• W2474289722 cites W2039932426 @default.
• W2474289722 cites W2044454707 @default.
• W2474289722 cites W2046272640 @default.
• W2474289722 cites W2046358190 @default.
• W2474289722 cites W2054585308 @default.
• W2474289722 cites W2059993172 @default.
• W2474289722 cites W2062666691 @default.
• W2474289722 cites W2064030857 @default.
• W2474289722 cites W2068700715 @default.
• W2474289722 cites W2069143195 @default.
• W2474289722 cites W2069270290 @default.
• W2474289722 cites W2070866396 @default.
• W2474289722 cites W2073762710 @default.
• W2474289722 cites W2073913517 @default.
• W2474289722 cites W2078785671 @default.
• W2474289722 cites W2079228339 @default.
• W2474289722 cites W2098544401 @default.
• W2474289722 cites W2098630374 @default.
• W2474289722 cites W2108073693 @default.
• W2474289722 cites W2109021882 @default.
• W2474289722 cites W2109312400 @default.
• W2474289722 cites W2111151469 @default.
• W2474289722 cites W2120061656 @default.
• W2474289722 cites W2120419643 @default.
• W2474289722 cites W2123547995 @default.
• W2474289722 cites W2129436053 @default.
• W2474289722 cites W2138848871 @default.
• W2474289722 cites W2139516496 @default.
• W2474289722 cites W2140353364 @default.
• W2474289722 cites W2145038392 @default.
• W2474289722 cites W2146519942 @default.
• W2474289722 cites W2150093310 @default.
• W2474289722 cites W2150693438 @default.
• W2474289722 cites W2157619122 @default.
• W2474289722 cites W2169110988 @default.
• W2474289722 cites W2193962986 @default.
• W2474289722 cites W2212629349 @default.
• W2474289722 cites W2288859094 @default.
• W2474289722 cites W2322777826 @default.
• W2474289722 cites W2325687759 @default.
• W2474289722 cites W2329148016 @default.
• W2474289722 cites W2333152051 @default.
• W2474289722 cites W2395078486 @default.
• W2474289722 cites W4241239017 @default.
• W2474289722 cites W4248107770 @default.
• W2474289722 cites W4249304889 @default.
• W2474289722 cites W992017291 @default.
• W2474289722 doi "https://doi.org/10.1016/j.bmc.2016.06.044" @default.
• W2474289722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27381365" @default.
• W2474289722 hasPublicationYear "2016" @default.
• W2474289722 type Work @default.
• W2474289722 sameAs 2474289722 @default.
• W2474289722 citedByCount "127" @default.

• next