FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474295836> ?p ?o ?g. }

• W2474295836 abstract "Nam Dia Long (NDL) is a Vietnamese traditional formula used for the treatment of some chronic diseases, including cancers, but which lacks evidence-based support. We investigated the selective cytotoxicity of NDL on some tumor cell lines and possible interactions among its ingredients leading to the overall activity. Crude aqueous extracts of NDL, its ingredients including Vigna radiata (L.) Wilczek, Vigna unguiculata (L.) Walp. subsp. unguiculata, Sauropus androgynous (L.) Merr and different ingredient combinations were used for the treatment of MCF-7, Hep G2, NCI-H460 cells and normal fibroblasts. The IC50 of NDL on tumor and normal cells were determined by sulforhodamine B (SRB) assay and used to calculate a selectivity index (SI). Apoptosis induction activity of NDL was determined by acridine orange - ethidium bromide (AO-EB) staining, genomic DNA and cell cycle analysis. The combination index (CI) reflecting the types of interactions among ingredients was calculated based on the median-effect principle. Real-time cell growth monitoring by the xCELLigence system was used to determine the kinetic profile of the treated MCF-7 cells. NDL exerted cytotoxicity on all tumor and normal cells, with the highest effect on MCF-7 cells. SI values for MCF-7, Hep G2 and NCI-H460 were 6.45, 1.61 and 1.29, respectively, indicating a high selective cytotoxicity of NDL toward MCF-7 cells. Profiles of cell death differed for MCF-7 cells and fibroblasts suggesting different mechanism of action of NDL toward these two cell types. The cytotoxicity of NDL against MCF-7 cells was due to apoptosis induction. NDL caused a cell cycle non-phase-specific effect on MCF-7 cells. CI indicated synergistic interactions among the ingredients leading to the overall activity of the complete formula. The real-time monitoring of MCF-7 cells growth after being treated with NDL and three-component combinations suggested that the presence of all ingredients was needed to reach the full cytotoxic activity. The growth kinetic profile of MCF-7 cells treated with different combinations also indicated a synergistic effect of all ingredients. NDL exhibited selective cytotoxicity toward MCF-7 cells. This effect probably resulted from synergistic interactions among the NDL ingredients. NDL should be explored for breast cancer treatment." @default.
• W2474295836 created "2016-07-22" @default.
• W2474295836 creator A5050346234 @default.
• W2474295836 creator A5078263828 @default.
• W2474295836 date "2016-07-16" @default.
• W2474295836 modified "2023-10-11" @default.
• W2474295836 title "Selective cytotoxicity of a Vietnamese traditional formula, Nam Dia long, against MCF-7 cells by synergistic effects" @default.
• W2474295836 cites W1611271948 @default.
• W2474295836 cites W1848425687 @default.
• W2474295836 cites W1975582371 @default.
• W2474295836 cites W1983424718 @default.
• W2474295836 cites W1996291531 @default.
• W2474295836 cites W2067939908 @default.
• W2474295836 cites W2069088530 @default.
• W2474295836 cites W2079792950 @default.
• W2474295836 cites W2080627325 @default.
• W2474295836 cites W2082295228 @default.
• W2474295836 cites W2094585066 @default.
• W2474295836 cites W2096646395 @default.
• W2474295836 cites W2103562758 @default.
• W2474295836 cites W2109689528 @default.
• W2474295836 cites W2118339175 @default.
• W2474295836 cites W2120180501 @default.
• W2474295836 cites W2121795258 @default.
• W2474295836 cites W2125417312 @default.
• W2474295836 cites W2143675738 @default.
• W2474295836 cites W2146984617 @default.
• W2474295836 cites W2152185680 @default.
• W2474295836 cites W2160978749 @default.
• W2474295836 cites W2166549828 @default.
• W2474295836 cites W2172156898 @default.
• W2474295836 cites W2184083116 @default.
• W2474295836 cites W3143798943 @default.
• W2474295836 cites W4210962289 @default.
• W2474295836 doi "https://doi.org/10.1186/s12906-016-1212-z" @default.
• W2474295836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4947304" @default.
• W2474295836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27421261" @default.
• W2474295836 hasPublicationYear "2016" @default.
• W2474295836 type Work @default.
• W2474295836 sameAs 2474295836 @default.
• W2474295836 citedByCount "29" @default.
• W2474295836 countsByYear W24742958362016 @default.
• W2474295836 countsByYear W24742958362017 @default.
• W2474295836 countsByYear W24742958362018 @default.
• W2474295836 countsByYear W24742958362019 @default.
• W2474295836 countsByYear W24742958362020 @default.
• W2474295836 countsByYear W24742958362021 @default.
• W2474295836 countsByYear W24742958362022 @default.
• W2474295836 countsByYear W24742958362023 @default.
• W2474295836 crossrefType "journal-article" @default.
• W2474295836 hasAuthorship W2474295836A5050346234 @default.
• W2474295836 hasAuthorship W2474295836A5078263828 @default.
• W2474295836 hasBestOaLocation W24742958361 @default.
• W2474295836 hasConcept C109316439 @default.
• W2474295836 hasConcept C153911025 @default.
• W2474295836 hasConcept C185592680 @default.
• W2474295836 hasConcept C190283241 @default.
• W2474295836 hasConcept C202751555 @default.
• W2474295836 hasConcept C2776074239 @default.
• W2474295836 hasConcept C2779102032 @default.
• W2474295836 hasConcept C2779862049 @default.
• W2474295836 hasConcept C2780783641 @default.
• W2474295836 hasConcept C54355233 @default.
• W2474295836 hasConcept C55493867 @default.
• W2474295836 hasConcept C556039675 @default.
• W2474295836 hasConcept C59822182 @default.
• W2474295836 hasConcept C62112901 @default.
• W2474295836 hasConcept C71924100 @default.
• W2474295836 hasConcept C81885089 @default.
• W2474295836 hasConcept C86803240 @default.
• W2474295836 hasConcept C98274493 @default.
• W2474295836 hasConceptScore W2474295836C109316439 @default.
• W2474295836 hasConceptScore W2474295836C153911025 @default.
• W2474295836 hasConceptScore W2474295836C185592680 @default.
• W2474295836 hasConceptScore W2474295836C190283241 @default.
• W2474295836 hasConceptScore W2474295836C202751555 @default.
• W2474295836 hasConceptScore W2474295836C2776074239 @default.
• W2474295836 hasConceptScore W2474295836C2779102032 @default.
• W2474295836 hasConceptScore W2474295836C2779862049 @default.
• W2474295836 hasConceptScore W2474295836C2780783641 @default.
• W2474295836 hasConceptScore W2474295836C54355233 @default.
• W2474295836 hasConceptScore W2474295836C55493867 @default.
• W2474295836 hasConceptScore W2474295836C556039675 @default.
• W2474295836 hasConceptScore W2474295836C59822182 @default.
• W2474295836 hasConceptScore W2474295836C62112901 @default.
• W2474295836 hasConceptScore W2474295836C71924100 @default.
• W2474295836 hasConceptScore W2474295836C81885089 @default.
• W2474295836 hasConceptScore W2474295836C86803240 @default.
• W2474295836 hasConceptScore W2474295836C98274493 @default.
• W2474295836 hasIssue "1" @default.
• W2474295836 hasLocation W24742958361 @default.
• W2474295836 hasLocation W24742958362 @default.
• W2474295836 hasLocation W24742958363 @default.
• W2474295836 hasLocation W24742958364 @default.
• W2474295836 hasOpenAccess W2474295836 @default.
• W2474295836 hasPrimaryLocation W24742958361 @default.
• W2474295836 hasRelatedWork W147422163 @default.
• W2474295836 hasRelatedWork W1933341309 @default.
• W2474295836 hasRelatedWork W1974029411 @default.
• W2474295836 hasRelatedWork W2257026133 @default.

• next