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- W2474451587 abstract "Objective: To explore the mechanisms of the beneficial effects of Dahuang Zhechong Pill(DHZCP), a Chinese patent herbal medicine, in treatment of chronic renal disease, and to investigate the effects of DHZCP on the expressions of renal tissue inhibitor of metalloproteinase-1 (TIMP-1) and plasminogen activator inhibitor-1(PAI-1) mRNAs in rats with adriamycin-induced glomerulosclerosis.Methods: Focal segmental glomerulosclerosis and diffuse mesangial proliferation were induced in rats by combined procedures, including unilateral nephrectomy, intravenous injection of adriamycin and giving high-fat foods. The rats were randomly divided into untreated group, benazepril-treated group and DHZCP-treated group. Another 6 rats were sham-operated as control group. After 12-week treatment, rats were sacrificed, reverse transcription polymerase chain reaction (RT-PCR) method and computerized image analytical technique were used to determine the expressions of TIMP-1 and PAI-1 mRNAs.Results: Compared with the untreated group, the ratios of TIMP-1/β-actin and PAI-1/β-actin of the DHZCP-treated group were decreased, suggesting that DHZCP could down-regulate the expressions of TIMP-1 and PAI-1 mRNAs (P＜0.05). Benazepril could significantly inhibit the expression of TIMP-1 mRNA compared with that of the untreated group (P＜0.05)Conclusion: DHZCP can down-regulate the expressions of TIMP-1 and PAI-1 mRNAs in renal tissues of rats with focal segmental glomerulosclerosis and diffuse mesangial proliferation, which may be its action mechanism in treating chronic renal disease." @default.
- W2474451587 created "2016-07-22" @default.
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- W2474451587 date "2008-05-15" @default.
- W2474451587 modified "2023-09-27" @default.
- W2474451587 title "大黄（庶虫）虫丸对肾小球硬化大鼠纤溶酶原激活物抑制物1和金属蛋白酶1组织抑制剂mRNA表达的影响" @default.
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