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- W2474506578 abstract "Aided by the advent of advanced mass spectrometry (MS)-based technologies and methodologies, quantitative proteomics has emerged as a viable technique to capture meaningful data for candidate biomarker evaluation. To aid clinical translation, these methods generally utilize a bottom-up strategy with isotopically labeled standards and a targeted form of MS measurement.This article reviews the status, challenges, requirements, and potential of translating current, MS-based methods to the clinical laboratory. The described methods are discussed and contrasted within a fit-for-purpose approach, while different resources for quality control, quantitative analysis, and data interpretation are additionally provided. Expert commentary: Although great strides have been made over the past five years in developing reliable quantitative assays for plasma protein biomarkers, it is crucial for investigators to have an understanding of the clinical validation process, a major roadblock in translational research. Continued progress in method design and validation of protein assays is necessary to ultimately achieve widespread adoption and regulatory approval." @default.
- W2474506578 created "2016-07-22" @default.
- W2474506578 creator A5033355265 @default.
- W2474506578 creator A5035423342 @default.
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- W2474506578 creator A5052663838 @default.
- W2474506578 creator A5074326062 @default.
- W2474506578 creator A5082314395 @default.
- W2474506578 creator A5087840752 @default.
- W2474506578 date "2016-07-02" @default.
- W2474506578 modified "2023-10-18" @default.
- W2474506578 title "Clinical translation of MS-based, quantitative plasma proteomics: status, challenges, requirements, and potential" @default.
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