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- W2474538858 abstract "The transcription factor, interferon regulatory factor-8 (IRF8), is required for the development of monocytes, macrophages, dendritic cells (DCs), basophils, and eosinophils, while it inhibits the generation of neutrophils. Recently, the molecular mechanisms by which IRF8 regulates their development have been increasingly clarified by genome-wide analyses, including chromatin immunoprecipitation-sequencing and transcriptome profiling. IRF8 associates with the myeloid master transcription factor, PU.1, to promote the establishment of cell-type-specific enhancers and gene expression, thereby driving monocyte development or maintaining the plasmacytoid DC-specific gene expression profiles. Furthermore, microbial stimulation enables IRF8 to associate with other transcription factors, including IRF1, to induce immune response genes. Knowledge about the regulation of Irf8 expression in myeloid development has also increased. In this review, we discuss recent advances in our understanding of transcriptional and epigenetic regulation involving IRF8 in the development of myeloid cells." @default.
- W2474538858 created "2016-07-22" @default.
- W2474538858 creator A5050855780 @default.
- W2474538858 creator A5067715504 @default.
- W2474538858 date "2016-07-01" @default.
- W2474538858 modified "2023-09-26" @default.
- W2474538858 title "Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8" @default.
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- W2474538858 doi "https://doi.org/10.1089/jir.2015.0138" @default.
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