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- W2474549202 endingPage "157" @default.
- W2474549202 startingPage "139" @default.
- W2474549202 abstract "Hirschsprung disease (HSCR, intestinal aganglionosis) is a multigenic disorder with variable penetrance and severity that has a general population incidence of 1/5000 live births. Studies using animal models have contributed to our understanding of the developmental origins of HSCR and the genetic complexity of this disease. This review summarizes recent progress in understanding control of enteric nervous system (ENS) development through analyses in mouse models. An overview of signaling pathways that have long been known to control the migration, proliferation and differentiation of enteric neural progenitors into and along the developing gut is provided as a framework for the latest information on factors that influence enteric ganglia formation and maintenance. Newly identified genes and additional factors beyond discrete genes that contribute to ENS pathology including regulatory sequences, miRNAs and environmental factors are also introduced. Finally, because HSCR has become a paradigm for complex oligogenic diseases with non-Mendelian inheritance, the importance of gene interactions, modifier genes, and initial studies on genetic background effects are outlined." @default.
- W2474549202 created "2016-07-22" @default.
- W2474549202 creator A5036108107 @default.
- W2474549202 creator A5067210987 @default.
- W2474549202 date "2016-09-01" @default.
- W2474549202 modified "2023-10-16" @default.
- W2474549202 title "Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players" @default.
- W2474549202 cites W1461548044 @default.
- W2474549202 cites W1570458334 @default.
- W2474549202 cites W1597960822 @default.
- W2474549202 cites W1665419471 @default.
- W2474549202 cites W1769601709 @default.
- W2474549202 cites W1828854597 @default.
- W2474549202 cites W1843210218 @default.
- W2474549202 cites W1866078083 @default.
- W2474549202 cites W1892969415 @default.
- W2474549202 cites W1949798014 @default.
- W2474549202 cites W1951867641 @default.
- W2474549202 cites W1966807310 @default.
- W2474549202 cites W1970085309 @default.
- W2474549202 cites W1972260378 @default.
- W2474549202 cites W1976989940 @default.
- W2474549202 cites W1977221588 @default.
- W2474549202 cites W1978571917 @default.
- W2474549202 cites W1978879498 @default.
- W2474549202 cites W1979816705 @default.
- W2474549202 cites W1979856980 @default.
- W2474549202 cites W1981367331 @default.
- W2474549202 cites W1982144815 @default.
- W2474549202 cites W1985065420 @default.
- W2474549202 cites W1985467463 @default.
- W2474549202 cites W1987566228 @default.
- W2474549202 cites W1989174024 @default.
- W2474549202 cites W1990117383 @default.
- W2474549202 cites W1990339051 @default.
- W2474549202 cites W1991750645 @default.
- W2474549202 cites W1993496211 @default.
- W2474549202 cites W1994436997 @default.
- W2474549202 cites W1995653718 @default.
- W2474549202 cites W1996960280 @default.
- W2474549202 cites W1999259704 @default.
- W2474549202 cites W1999693507 @default.
- W2474549202 cites W2000690214 @default.
- W2474549202 cites W2004881323 @default.
- W2474549202 cites W2004901650 @default.
- W2474549202 cites W2004965883 @default.
- W2474549202 cites W2005722218 @default.
- W2474549202 cites W2006685944 @default.
- W2474549202 cites W2008118174 @default.
- W2474549202 cites W2009343186 @default.
- W2474549202 cites W2011813261 @default.
- W2474549202 cites W2012896813 @default.
- W2474549202 cites W2015356732 @default.
- W2474549202 cites W2017458728 @default.
- W2474549202 cites W2018139276 @default.
- W2474549202 cites W2018214833 @default.
- W2474549202 cites W2019235974 @default.
- W2474549202 cites W2020027399 @default.
- W2474549202 cites W2020066516 @default.
- W2474549202 cites W2020850747 @default.
- W2474549202 cites W2022591348 @default.
- W2474549202 cites W2023537470 @default.
- W2474549202 cites W2024091637 @default.
- W2474549202 cites W2025054473 @default.
- W2474549202 cites W2025120315 @default.
- W2474549202 cites W2025688045 @default.
- W2474549202 cites W2027322371 @default.
- W2474549202 cites W2027481001 @default.
- W2474549202 cites W2029157857 @default.
- W2474549202 cites W2029612353 @default.
- W2474549202 cites W2030451152 @default.
- W2474549202 cites W2030996806 @default.
- W2474549202 cites W2031410359 @default.
- W2474549202 cites W2034040733 @default.
- W2474549202 cites W2036137707 @default.
- W2474549202 cites W2037438254 @default.
- W2474549202 cites W2038286386 @default.
- W2474549202 cites W2038304451 @default.
- W2474549202 cites W2038510087 @default.
- W2474549202 cites W2038777362 @default.
- W2474549202 cites W2039790417 @default.
- W2474549202 cites W2041338047 @default.
- W2474549202 cites W2042506656 @default.
- W2474549202 cites W2043072647 @default.
- W2474549202 cites W2044449598 @default.
- W2474549202 cites W2045756232 @default.
- W2474549202 cites W2046739515 @default.
- W2474549202 cites W2050275568 @default.
- W2474549202 cites W2050446042 @default.
- W2474549202 cites W2051998916 @default.
- W2474549202 cites W2052252748 @default.
- W2474549202 cites W2054593736 @default.
- W2474549202 cites W2055845895 @default.
- W2474549202 cites W2056420557 @default.
- W2474549202 cites W2058157535 @default.
- W2474549202 cites W2059073891 @default.
- W2474549202 cites W2062518659 @default.
- W2474549202 cites W2063202145 @default.