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- W247473604 abstract "This chapter discusses the prenatal adverse effects of nicotine on the developing brain. Nicotine acts on many different central and peripheral processes in the adult organism. Its developmental effects can be expected to result from an interaction of direct effects on the developing brain with actions of nutrition, metabolism and endocrine systems of both fetal and maternal organisms, including the placenta. Nicotine affects the materno-fetal unit through multiple actions. Specific direct actions of nicotine on the developing brain seem possible during a major part of prenatal life, because binding sites for [3H] nicotine are already detectable in the central nervous system of the rat at late embryonic stages. Actions of nicotine at central cholinergic receptor sites combine in a complex way with effects of the drug on circulation, metabolism and endocrine systems of mother and fetus. Children of mothers who smoked during pregnancy display symptoms of minimal brain dysfunction or attention deficit disorder (ADD). Analogous behavioral abnormalities are found in prenatally nicotine-exposed animals." @default.
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- W247473604 date "1988-01-01" @default.
- W247473604 modified "2023-10-16" @default.
- W247473604 title "Prenatal adverse effects of nicotine on the developing brain" @default.
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- W247473604 doi "https://doi.org/10.1016/s0079-6123(08)60502-6" @default.
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