Matches in SemOpenAlex for { <https://semopenalex.org/work/W247481841> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W247481841 endingPage "7" @default.
- W247481841 startingPage "1" @default.
- W247481841 abstract "Equine platelets, when treated with the anthelmintic drug diethylcarbamazine (DEC), gave a dose-dependent release of radiolabeled serotonin without concomitant aggregation. At levels of the drug that gave only minimal release of radiolabel, marked dose-dependent inhibition of platelet aggregation to three of four platelet agonists tested--adenosine diphosphate (ADP), collagen, and arachidonic acid--was observed. With ADP, inhibition was observed to be reversed by removal of DEC prior to agonist challenge. However, with collagen, inhibition was only partially reduced by prior removal of DEC; whereas with arachidonate the DEC inhibition appeared not to be reduced by removal of the drug. Thrombin-induced aggregation was not inhibited by DEC. DEC therefore has the heretofore unrecognized property of modulating platelet function to several platelet agonists as well as inducing the platelet release of serotonin. Our results would suggest a reversible membrane-drug interaction as the potential site of modulation for ADP and collagen, whereas an apparent irreversible inhibition is suggested for arachidonate-induced aggregation." @default.
- W247481841 created "2016-06-24" @default.
- W247481841 creator A5006754891 @default.
- W247481841 creator A5022833024 @default.
- W247481841 creator A5033449288 @default.
- W247481841 creator A5079494932 @default.
- W247481841 date "1983-10-01" @default.
- W247481841 modified "2023-10-14" @default.
- W247481841 title "Modulation of equine platelet function by diethylcarbamazine (DEC)." @default.
- W247481841 cites W1977188587 @default.
- W247481841 cites W1980201737 @default.
- W247481841 cites W2013690609 @default.
- W247481841 cites W2014492191 @default.
- W247481841 cites W2018751413 @default.
- W247481841 cites W2023760281 @default.
- W247481841 cites W2044595209 @default.
- W247481841 cites W2067628062 @default.
- W247481841 cites W2073105459 @default.
- W247481841 cites W2077459776 @default.
- W247481841 cites W2117694083 @default.
- W247481841 cites W2138764121 @default.
- W247481841 cites W2317951392 @default.
- W247481841 cites W2336297373 @default.
- W247481841 cites W2343368844 @default.
- W247481841 cites W2407496251 @default.
- W247481841 cites W2415033676 @default.
- W247481841 cites W4230843501 @default.
- W247481841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1916298" @default.
- W247481841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6414306" @default.
- W247481841 hasPublicationYear "1983" @default.
- W247481841 type Work @default.
- W247481841 sameAs 247481841 @default.
- W247481841 citedByCount "2" @default.
- W247481841 crossrefType "journal-article" @default.
- W247481841 hasAuthorship W247481841A5006754891 @default.
- W247481841 hasAuthorship W247481841A5022833024 @default.
- W247481841 hasAuthorship W247481841A5033449288 @default.
- W247481841 hasAuthorship W247481841A5079494932 @default.
- W247481841 hasConcept C126322002 @default.
- W247481841 hasConcept C134018914 @default.
- W247481841 hasConcept C170493617 @default.
- W247481841 hasConcept C181199279 @default.
- W247481841 hasConcept C185592680 @default.
- W247481841 hasConcept C2775864247 @default.
- W247481841 hasConcept C2777292125 @default.
- W247481841 hasConcept C2777399203 @default.
- W247481841 hasConcept C2778078955 @default.
- W247481841 hasConcept C2780035454 @default.
- W247481841 hasConcept C2993802102 @default.
- W247481841 hasConcept C55493867 @default.
- W247481841 hasConcept C71924100 @default.
- W247481841 hasConcept C86803240 @default.
- W247481841 hasConcept C89560881 @default.
- W247481841 hasConcept C98274493 @default.
- W247481841 hasConceptScore W247481841C126322002 @default.
- W247481841 hasConceptScore W247481841C134018914 @default.
- W247481841 hasConceptScore W247481841C170493617 @default.
- W247481841 hasConceptScore W247481841C181199279 @default.
- W247481841 hasConceptScore W247481841C185592680 @default.
- W247481841 hasConceptScore W247481841C2775864247 @default.
- W247481841 hasConceptScore W247481841C2777292125 @default.
- W247481841 hasConceptScore W247481841C2777399203 @default.
- W247481841 hasConceptScore W247481841C2778078955 @default.
- W247481841 hasConceptScore W247481841C2780035454 @default.
- W247481841 hasConceptScore W247481841C2993802102 @default.
- W247481841 hasConceptScore W247481841C55493867 @default.
- W247481841 hasConceptScore W247481841C71924100 @default.
- W247481841 hasConceptScore W247481841C86803240 @default.
- W247481841 hasConceptScore W247481841C89560881 @default.
- W247481841 hasConceptScore W247481841C98274493 @default.
- W247481841 hasIssue "1" @default.
- W247481841 hasLocation W2474818411 @default.
- W247481841 hasOpenAccess W247481841 @default.
- W247481841 hasPrimaryLocation W2474818411 @default.
- W247481841 hasRelatedWork W1489735188 @default.
- W247481841 hasRelatedWork W1964834903 @default.
- W247481841 hasRelatedWork W2011944663 @default.
- W247481841 hasRelatedWork W2093106202 @default.
- W247481841 hasRelatedWork W2104077162 @default.
- W247481841 hasRelatedWork W2299758909 @default.
- W247481841 hasRelatedWork W2401073577 @default.
- W247481841 hasRelatedWork W247481841 @default.
- W247481841 hasRelatedWork W4237594678 @default.
- W247481841 hasRelatedWork W956296439 @default.
- W247481841 hasVolume "113" @default.
- W247481841 isParatext "false" @default.
- W247481841 isRetracted "false" @default.
- W247481841 magId "247481841" @default.
- W247481841 workType "article" @default.