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• W2474820107 abstract "Beta-hydroxy-beta-methylbutyrate(HMB) supplement had extensively use as ergogenic aids among athlete and fitness population. Previous researches indicated that HMB not only enhance muscular fitness but also affect bone homeostasis. HMB enhanced bone formation through IGF pathway and inhibit bone resorption through unknown mechanism. Previous studies indicated that HMB downregulate osteoclastogenesis by inhibit NF-kB pathway and downstream protein expression. Downstream expression of dendritic cell-specific transmembrane protein (DC-STAMP) which responsible for cell to cell fusion during osteoclastogenesis might be the downregulation target of HMB in NF-kB pathway. Therefore, we design present study to investigate effects of HMB supplement on NF-kB related protein expression in peripheral blood mononuclear cell (PBMC). 12 healthy college male aged 20-22 years old were recruited as subject for present study. All subjects intake 3 grams of HMB daily in the early morning for 14 days and daily diet were recorded. Fasting blood samples were collected through venipuncture on day 2, 3, 4, 6, 8, 11, 15 and 1, 2, 3, 6, 9, 12 hours after HMB supplement on day 1. Plasma osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kB ligand (sRANKL) level were analyzed by ELISA. Receptor activator of nuclear factor kB (RANK) and DC-STAMP expression on PBMC surface were analyzed by Flow cytometer. RANK expression on PBMC was significantly decreased within 6 hours and remains lower than baseline for the next two days. DC-STAMP expression on PBMC also decreased within 6 hours after HMB ingestion and remains lower than normal for the next two days as well. Plasma sRANKL and OPG level remain stable for entire supplement period. Results of present study indicated that HMB supplement downregulate the expression of RANK and DC-STAMP, both upstream and downstream protein of NF-kB pathway without alter sRANKL and OPG level. Current results indicated that downregulate of osteoclastogenesis by short-term HMB supplement might media through NF-kB pathway. However, plasma sRANKL and OPG level were not altered. Effects of long term HMB supplement on osteoclastogenesis require further study to Clarify. Effects of HMB supplement on bone metabolism related cells such as stroma cells and osteoblast require further study as well." @default.
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• W2474820107 date "2016-05-01" @default.
• W2474820107 modified "2023-10-17" @default.
• W2474820107 title "Effect Of 14 Days Hmb Supplement On Osteoclastogenesis Related Protein Expression And Bone Metabolism Regulate Cytokines Level In Healthy College Male." @default.
• W2474820107 doi "https://doi.org/10.1249/01.mss.0000485170.85722.59" @default.
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