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• W2474823081 abstract "Introduction: Increasing evidence suggests that Alzheimer’s disease (AD) may begin decades before evidence of dementia, indicating that it may be a disorder of midlife rather than old age. Methods: Intheabsence oflong-termprospectivestudiesfromearly adulthoodspecifically designed to address this question, a group of international experts examined evidence presently available from previous clinical and population studies to provide an evidence-based opinion as to whether such a change in conceptualization may be justified. Results: Although still lacking confirmation from dedicated prospective biomarker studies, there is already considerable evidence to suggest both risk factor exposure and brain changes may be already present in midlife. Discussion: Current evidence suggests (1) that a change in clinical approach notably involving promotion of cardiovascular health in persons with a family history of AD may considerably reduce disease risk and (2) that the development of biomarkers at this early stage will lead to the possibility of clinical trials at a much earlier stage. 2015TheAuthors.PublishedbyElsevierInc.onbehalfoftheAlzheimer’sAssociation.Thisisanopen access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)." @default.
• W2474823081 created "2016-07-22" @default.
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• W2474823081 date "2015-01-01" @default.
• W2474823081 modified "2023-09-27" @default.
• W2474823081 title "Review Article Is late-onset Alzheimer's disease really a disease of midlife?" @default.
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