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- W2474824026 endingPage "17705" @default.
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- W2474824026 abstract "Epigenetic systems are well known for the roles they play in regulating the differential expression of the same genome in different cell types. However, epigenetic systems can also directly impact genomic integrity by protecting genetic sequences. Using an experimental evolutionary approach, we studied rates of mutation in the fission yeast Schizosaccharomyces pombe strains that lacked genes encoding several epigenetic regulators or mismatch repair components. We report that loss of a functional mismatch repair pathway in S. pombe resulted in the preferential enrichment of mutations in euchromatin, indicating that the mismatch repair machinery preferentially protected genetic fidelity in euchromatin. This preference is probably determined by differences in the accessibility of chromatin at distinct chromatin regions, which is supported by our observations that chromatin accessibility positively correlated with mutation rates in S. pombe or human cancer samples with deficiencies in mismatch repair. Importantly, such positive correlation was not observed in S. pombe strains or human cancer samples with functional mismatch repair machinery." @default.
- W2474824026 created "2016-07-22" @default.
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- W2474824026 date "2016-08-01" @default.
- W2474824026 modified "2023-10-12" @default.
- W2474824026 title "Preferential Protection of Genetic Fidelity within Open Chromatin by the Mismatch Repair Machinery" @default.
- W2474824026 cites W1509550144 @default.
- W2474824026 cites W160239957 @default.
- W2474824026 cites W1861303592 @default.
- W2474824026 cites W1975781028 @default.
- W2474824026 cites W1977492313 @default.
- W2474824026 cites W1978197643 @default.
- W2474824026 cites W1979524912 @default.
- W2474824026 cites W1989456683 @default.
- W2474824026 cites W1989563297 @default.
- W2474824026 cites W1993105831 @default.
- W2474824026 cites W1997478924 @default.
- W2474824026 cites W1999284470 @default.
- W2474824026 cites W1999529939 @default.
- W2474824026 cites W2000391750 @default.
- W2474824026 cites W2004297150 @default.
- W2474824026 cites W2005342820 @default.
- W2474824026 cites W2006789046 @default.
- W2474824026 cites W2008409661 @default.
- W2474824026 cites W2009096224 @default.
- W2474824026 cites W2009187135 @default.
- W2474824026 cites W2009720434 @default.
- W2474824026 cites W2010027764 @default.
- W2474824026 cites W2010067945 @default.
- W2474824026 cites W2013939194 @default.
- W2474824026 cites W2014439672 @default.
- W2474824026 cites W2015735754 @default.
- W2474824026 cites W2021146265 @default.
- W2474824026 cites W2027299912 @default.
- W2474824026 cites W2029301727 @default.
- W2474824026 cites W2031142206 @default.
- W2474824026 cites W2032385067 @default.
- W2474824026 cites W2036897871 @default.
- W2474824026 cites W2037898576 @default.
- W2474824026 cites W2039875081 @default.
- W2474824026 cites W2040234712 @default.
- W2474824026 cites W2042793731 @default.
- W2474824026 cites W2044198642 @default.
- W2474824026 cites W2053903416 @default.
- W2474824026 cites W2055223560 @default.
- W2474824026 cites W2057185906 @default.
- W2474824026 cites W2064297857 @default.
- W2474824026 cites W2068625350 @default.
- W2474824026 cites W2069333788 @default.
- W2474824026 cites W2077455530 @default.
- W2474824026 cites W2078539443 @default.
- W2474824026 cites W2080028600 @default.
- W2474824026 cites W2081445906 @default.
- W2474824026 cites W2083033591 @default.
- W2474824026 cites W2085315842 @default.
- W2474824026 cites W2085554251 @default.
- W2474824026 cites W2086239585 @default.
- W2474824026 cites W2091117089 @default.
- W2474824026 cites W2093146349 @default.
- W2474824026 cites W2095806089 @default.
- W2474824026 cites W2096731080 @default.
- W2474824026 cites W2097205777 @default.
- W2474824026 cites W2100303227 @default.
- W2474824026 cites W2101784201 @default.
- W2474824026 cites W2103441770 @default.
- W2474824026 cites W2105656306 @default.
- W2474824026 cites W2108234281 @default.
- W2474824026 cites W2112331024 @default.
- W2474824026 cites W2114632170 @default.
- W2474824026 cites W2116402707 @default.
- W2474824026 cites W2120807753 @default.
- W2474824026 cites W2124985265 @default.
- W2474824026 cites W2127230663 @default.
- W2474824026 cites W2127604631 @default.
- W2474824026 cites W2133178637 @default.
- W2474824026 cites W2134527371 @default.
- W2474824026 cites W2139964075 @default.
- W2474824026 cites W2141798197 @default.
- W2474824026 cites W2143828280 @default.
- W2474824026 cites W2144386534 @default.
- W2474824026 cites W2161248563 @default.
- W2474824026 cites W2162098634 @default.
- W2474824026 cites W2166728690 @default.
- W2474824026 cites W2168062956 @default.
- W2474824026 cites W2168133698 @default.
- W2474824026 cites W2168909179 @default.
- W2474824026 cites W2172146316 @default.
- W2474824026 cites W2259938310 @default.
- W2474824026 cites W2321385422 @default.
- W2474824026 cites W4254593962 @default.
- W2474824026 doi "https://doi.org/10.1074/jbc.m116.719971" @default.
- W2474824026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5016164" @default.
- W2474824026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27382058" @default.