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- W2474833581 abstract "Continuous identification of specific targets and candidate genes together with novel approaches offers new promises for the future of gene therapy design in Behçet's disease (BD). Personalized medicine based on pharmacogenomics is being developed at the clinical stage to improve treatment response. Screening the whole gene and regulatory regions is important when searching for novel variants associated with such complex diseases. Different host genetic factors play significant roles in susceptibility to BD. Thus, identifying these genes responsible for susceptibility and resistance to BD may offer a notable contribution toward understanding its pathogenesis, and may lead to the development of novel prophylactic and treatment strategies. Evidenced-based treatment strategy is recommended for the management in BD patients. This review sheds light on the immunopathogenesis and pharmacogenetics of BD with special attention to the treatment targeting gene polymorphisms. In conclusion, the potential of genetically guided treatment in BD takes us back to the future for an accurate management strategy of this serious rheumatic disease. The ongoing discovery of pivotal genes related to the susceptibility, manifestations, disease activity and treatment options provide substantial hope to the reduced frequency of BD, effective control and improvement in the prognosis. Targeted gene therapy could be a leading option in the treatment armamentarium of BD." @default.
- W2474833581 created "2016-07-22" @default.
- W2474833581 creator A5019320325 @default.
- W2474833581 creator A5040352583 @default.
- W2474833581 creator A5050427310 @default.
- W2474833581 date "2016-07-01" @default.
- W2474833581 modified "2023-10-14" @default.
- W2474833581 title "The potential of genetically guided treatment in Behçet's disease" @default.
- W2474833581 cites W1177626427 @default.
- W2474833581 cites W1455231073 @default.
- W2474833581 cites W1547617634 @default.
- W2474833581 cites W1553859547 @default.
- W2474833581 cites W1587348330 @default.
- W2474833581 cites W1697078030 @default.
- W2474833581 cites W1965172392 @default.
- W2474833581 cites W1967216529 @default.
- W2474833581 cites W1968893079 @default.
- W2474833581 cites W1973167129 @default.
- W2474833581 cites W1974060505 @default.
- W2474833581 cites W1976409931 @default.
- W2474833581 cites W1978539717 @default.
- W2474833581 cites W1979008253 @default.
- W2474833581 cites W1980056702 @default.
- W2474833581 cites W1981484726 @default.
- W2474833581 cites W1988577661 @default.
- W2474833581 cites W2001946532 @default.
- W2474833581 cites W2006150593 @default.
- W2474833581 cites W2012690578 @default.
- W2474833581 cites W2017153775 @default.
- W2474833581 cites W2018957399 @default.
- W2474833581 cites W2019413423 @default.
- W2474833581 cites W2020465148 @default.
- W2474833581 cites W2020542070 @default.
- W2474833581 cites W2023596169 @default.
- W2474833581 cites W2025813691 @default.
- W2474833581 cites W2030660441 @default.
- W2474833581 cites W2034069122 @default.
- W2474833581 cites W2039534215 @default.
- W2474833581 cites W2041820432 @default.
- W2474833581 cites W2042783830 @default.
- W2474833581 cites W2045850959 @default.
- W2474833581 cites W2051837180 @default.
- W2474833581 cites W2062103878 @default.
- W2474833581 cites W2062252451 @default.
- W2474833581 cites W2062832685 @default.
- W2474833581 cites W2063228908 @default.
- W2474833581 cites W2065059951 @default.
- W2474833581 cites W2066332211 @default.
- W2474833581 cites W2066416560 @default.
- W2474833581 cites W2066883715 @default.
- W2474833581 cites W2070540452 @default.
- W2474833581 cites W2078925701 @default.
- W2474833581 cites W2080920499 @default.
- W2474833581 cites W2081978538 @default.
- W2474833581 cites W2083278536 @default.
- W2474833581 cites W2086373018 @default.
- W2474833581 cites W2087069281 @default.
- W2474833581 cites W2093156856 @default.
- W2474833581 cites W2096874324 @default.
- W2474833581 cites W2097385117 @default.
- W2474833581 cites W2098497591 @default.
- W2474833581 cites W2100159336 @default.
- W2474833581 cites W2101191856 @default.
- W2474833581 cites W2102629834 @default.
- W2474833581 cites W2111085842 @default.
- W2474833581 cites W2112258866 @default.
- W2474833581 cites W2113938735 @default.
- W2474833581 cites W2119190184 @default.
- W2474833581 cites W2123341694 @default.
- W2474833581 cites W2123918812 @default.
- W2474833581 cites W2126326247 @default.
- W2474833581 cites W2131251800 @default.
- W2474833581 cites W2135293264 @default.
- W2474833581 cites W2136219369 @default.
- W2474833581 cites W2142473469 @default.
- W2474833581 cites W2143190437 @default.
- W2474833581 cites W2146886863 @default.
- W2474833581 cites W2147925519 @default.
- W2474833581 cites W2149619712 @default.
- W2474833581 cites W2150247134 @default.
- W2474833581 cites W2150495335 @default.
- W2474833581 cites W2151080688 @default.
- W2474833581 cites W2152955944 @default.
- W2474833581 cites W2154534238 @default.
- W2474833581 cites W2160552004 @default.
- W2474833581 cites W2162283840 @default.
- W2474833581 cites W2162767741 @default.
- W2474833581 cites W2166962278 @default.
- W2474833581 cites W2185836077 @default.
- W2474833581 cites W2328134265 @default.
- W2474833581 cites W4233005124 @default.
- W2474833581 cites W4244113530 @default.
- W2474833581 cites W4245289916 @default.
- W2474833581 doi "https://doi.org/10.2217/pgs-2015-0004" @default.
- W2474833581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27347725" @default.
- W2474833581 hasPublicationYear "2016" @default.
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