Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474833598> ?p ?o ?g. }
- W2474833598 endingPage "e12643" @default.
- W2474833598 startingPage "e12643" @default.
- W2474833598 abstract "Influenza A virus evades host antiviral defense through hijacking innate immunity by its non-structural protein 1 (NS1). By using mass spectrometry, threonine 80 (T80) was identified as a novel phosphorylated residue in the NS1 of the influenza virus A/WSN/1933(H1N1). By generating recombinant influenza viruses encoding NS1 T80 mutants, the roles of this phosphorylation site were characterized during viral replication. The T80E (phosphomimetic) mutant attenuated virus replication, whereas the T80A (non-phosphorylatable) mutant did not. Similar phenotypes were observed for these mutants in a mouse model experiment. In further study, the T80E mutant decreased the binding capacity between NS1 and viral nucleoprotein (NP), leading to impaired viral ribonucleoprotein (vRNP)-mediated viral transcription. The T80E mutant was also unable to inhibit interferon (IFN) production by reducing the binding affinity between NS1 and retinoic acid-induced gene 1 protein (RIG-I), causing attenuation of virus replication. Taken together, the present study reveals that T80 phosphorylation of NS1 reduced influenza virus replication through controlling RIG-I-mediated IFN production and vRNP activity." @default.
- W2474833598 created "2016-07-22" @default.
- W2474833598 creator A5002744113 @default.
- W2474833598 creator A5008726894 @default.
- W2474833598 creator A5012009078 @default.
- W2474833598 creator A5012677271 @default.
- W2474833598 creator A5015095796 @default.
- W2474833598 creator A5015873777 @default.
- W2474833598 creator A5032020402 @default.
- W2474833598 creator A5038776482 @default.
- W2474833598 creator A5039807506 @default.
- W2474833598 creator A5055773317 @default.
- W2474833598 creator A5061425549 @default.
- W2474833598 creator A5071951396 @default.
- W2474833598 creator A5090736523 @default.
- W2474833598 date "2016-08-04" @default.
- W2474833598 modified "2023-10-18" @default.
- W2474833598 title "Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I" @default.
- W2474833598 cites W1541737343 @default.
- W2474833598 cites W1571866243 @default.
- W2474833598 cites W1965489078 @default.
- W2474833598 cites W1966807407 @default.
- W2474833598 cites W1973383826 @default.
- W2474833598 cites W1976290313 @default.
- W2474833598 cites W1989231026 @default.
- W2474833598 cites W1995744610 @default.
- W2474833598 cites W1997835441 @default.
- W2474833598 cites W2001788095 @default.
- W2474833598 cites W2013117253 @default.
- W2474833598 cites W2015556811 @default.
- W2474833598 cites W2021290640 @default.
- W2474833598 cites W2023742017 @default.
- W2474833598 cites W2031317676 @default.
- W2474833598 cites W2031672204 @default.
- W2474833598 cites W2034649150 @default.
- W2474833598 cites W2040784160 @default.
- W2474833598 cites W2042571647 @default.
- W2474833598 cites W2048478321 @default.
- W2474833598 cites W2057890017 @default.
- W2474833598 cites W2059303389 @default.
- W2474833598 cites W2070343911 @default.
- W2474833598 cites W2083437974 @default.
- W2474833598 cites W2086678405 @default.
- W2474833598 cites W2089911961 @default.
- W2474833598 cites W2098715150 @default.
- W2474833598 cites W2107277218 @default.
- W2474833598 cites W2110214166 @default.
- W2474833598 cites W2112078820 @default.
- W2474833598 cites W2115612309 @default.
- W2474833598 cites W2118551141 @default.
- W2474833598 cites W2129561604 @default.
- W2474833598 cites W2132637063 @default.
- W2474833598 cites W2133106116 @default.
- W2474833598 cites W2140343664 @default.
- W2474833598 cites W2145004752 @default.
- W2474833598 cites W2147123985 @default.
- W2474833598 cites W2148985310 @default.
- W2474833598 cites W2155865514 @default.
- W2474833598 cites W2158679705 @default.
- W2474833598 cites W2163853272 @default.
- W2474833598 cites W2167983086 @default.
- W2474833598 doi "https://doi.org/10.1111/cmi.12643" @default.
- W2474833598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27376632" @default.
- W2474833598 hasPublicationYear "2016" @default.
- W2474833598 type Work @default.
- W2474833598 sameAs 2474833598 @default.
- W2474833598 citedByCount "22" @default.
- W2474833598 countsByYear W24748335982017 @default.
- W2474833598 countsByYear W24748335982018 @default.
- W2474833598 countsByYear W24748335982019 @default.
- W2474833598 countsByYear W24748335982020 @default.
- W2474833598 countsByYear W24748335982021 @default.
- W2474833598 countsByYear W24748335982022 @default.
- W2474833598 countsByYear W24748335982023 @default.
- W2474833598 crossrefType "journal-article" @default.
- W2474833598 hasAuthorship W2474833598A5002744113 @default.
- W2474833598 hasAuthorship W2474833598A5008726894 @default.
- W2474833598 hasAuthorship W2474833598A5012009078 @default.
- W2474833598 hasAuthorship W2474833598A5012677271 @default.
- W2474833598 hasAuthorship W2474833598A5015095796 @default.
- W2474833598 hasAuthorship W2474833598A5015873777 @default.
- W2474833598 hasAuthorship W2474833598A5032020402 @default.
- W2474833598 hasAuthorship W2474833598A5038776482 @default.
- W2474833598 hasAuthorship W2474833598A5039807506 @default.
- W2474833598 hasAuthorship W2474833598A5055773317 @default.
- W2474833598 hasAuthorship W2474833598A5061425549 @default.
- W2474833598 hasAuthorship W2474833598A5071951396 @default.
- W2474833598 hasAuthorship W2474833598A5090736523 @default.
- W2474833598 hasBestOaLocation W24748335981 @default.
- W2474833598 hasConcept C104317684 @default.
- W2474833598 hasConcept C11960822 @default.
- W2474833598 hasConcept C140704245 @default.
- W2474833598 hasConcept C143065580 @default.
- W2474833598 hasConcept C153911025 @default.
- W2474833598 hasConcept C159047783 @default.
- W2474833598 hasConcept C2522874641 @default.
- W2474833598 hasConcept C2777546802 @default.
- W2474833598 hasConcept C55493867 @default.