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• W2474839178 abstract "5514 Background: The prognosis of EC is excellent and mainly driven by early stage type I EC. However, for type II or advanced EC, relapses are frequent. Genomic studies so far included mainly early stage good prognosis primary tumors. Here, we aimed to characterize genetic alterations in high risk advanced or recurrent EC, determine the rate of co-occurring mutations and evaluate concordance between primary and metastatic sites. Methods: High risk EC patients were identified from the IGR tumor bank and defined as stage III or IV, or any stage with subsequent relapse. Samples with >30% cellularity were subjected to Sanger sequencing on 79 exons from 13 genes (KRAS, NRAS, HRAS, BRAF, AKT1, PIK3CA, PIK3R1, PIK3R2, PTEN, STK11, ESR1, TP53, FGFR2). Mutation calls were confirmed by an independent analysis. Results: 75 samples from 57 patients (pts) representative of high risk EC were identified: 49% (28/57) were type II EC, 70% were stage III/IV and the remaining stage I/II pts had all relapsed. By comparison,..." @default.
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• W2474839178 date "2014-05-20" @default.
• W2474839178 modified "2023-10-16" @default.
• W2474839178 title "Advanced or recurrent endometrial cancer (EC) and co-occurring mutations in multiple oncogenic pathways." @default.
• W2474839178 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.5514" @default.
• W2474839178 hasPublicationYear "2014" @default.
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