FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474848014> ?p ?o ?g. }

• W2474848014 endingPage "6713" @default.
• W2474848014 startingPage "6701" @default.
• W2474848014 abstract "Key points Kv1.2 and related voltage‐gated potassium channels have a highly conserved N‐linked glycosylation site in the first extracellular loop, with complex glycosylation in COS‐7 cells similar to endogenous Kv1.2 glycosylation in hippocampal neurons. COS‐7 cells expressing Kv1.2 show a crucial role of this N‐linked glycosylation in the forward trafficking of Kv1.2 to the cell membrane. Although both wild‐type and non‐glycosylated mutant Kv1.2 channels that have reached the cell membrane are internalized at a comparable rate, mutant channels are degraded at a faster rate. Treatment of wild‐type Kv1.2 channels on the cell surface with glycosidase to remove sialic acids also results in the faster degradation of internalized channels. Glycosylation of Kv1.2 is important with respect to facilitating trafficking to the cell membrane and enhancing the stability of channels that have reached the cell membrane. Abstract Studies in cultured hippocampal neurons and the COS‐7 cell line demonstrate important roles for N‐linked glycosylation of Kv1.2 channels in forward trafficking and protein degradation. Kv1.2 channels can contain complex N‐linked glycans, which facilitate cell surface expression of the channels. Additionally, the protein stability of cell surface‐expressed Kv1.2 channels is affected by glycosylation via differences in the degradation of internalized channels. The present study reveals the importance of N‐linked complex glycosylation in boosting Kv1.2 channel density. Notably, sialic acids at the terminal sugar branches play an important role in dampening the degradation of Kv1.2 internalized from the cell membrane to promote its stability." @default.
• W2474848014 created "2016-07-22" @default.
• W2474848014 creator A5001265999 @default.
• W2474848014 creator A5037141307 @default.
• W2474848014 creator A5041305380 @default.
• W2474848014 date "2016-08-02" @default.
• W2474848014 modified "2023-10-03" @default.
• W2474848014 title "N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels" @default.
• W2474848014 cites W1027035806 @default.
• W2474848014 cites W1496805086 @default.
• W2474848014 cites W1586412629 @default.
• W2474848014 cites W1664511950 @default.
• W2474848014 cites W1695869529 @default.
• W2474848014 cites W1779969084 @default.
• W2474848014 cites W1965625220 @default.
• W2474848014 cites W1970809926 @default.
• W2474848014 cites W1982894992 @default.
• W2474848014 cites W1986991195 @default.
• W2474848014 cites W1997940647 @default.
• W2474848014 cites W2002456177 @default.
• W2474848014 cites W2012168396 @default.
• W2474848014 cites W2015540983 @default.
• W2474848014 cites W2026810894 @default.
• W2474848014 cites W2030102659 @default.
• W2474848014 cites W2031765503 @default.
• W2474848014 cites W2053695860 @default.
• W2474848014 cites W2066433833 @default.
• W2474848014 cites W2071752662 @default.
• W2474848014 cites W2097205797 @default.
• W2474848014 cites W2099587101 @default.
• W2474848014 cites W2113568840 @default.
• W2474848014 cites W2119748918 @default.
• W2474848014 cites W2139866700 @default.
• W2474848014 cites W2149111266 @default.
• W2474848014 cites W2155979828 @default.
• W2474848014 cites W2157952220 @default.
• W2474848014 cites W2170324007 @default.
• W2474848014 cites W2305968748 @default.
• W2474848014 cites W2319164970 @default.
• W2474848014 cites W4245660285 @default.
• W2474848014 doi "https://doi.org/10.1113/jp272394" @default.
• W2474848014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5108895" @default.
• W2474848014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27377235" @default.
• W2474848014 hasPublicationYear "2016" @default.
• W2474848014 type Work @default.
• W2474848014 sameAs 2474848014 @default.
• W2474848014 citedByCount "14" @default.
• W2474848014 countsByYear W24748480142017 @default.
• W2474848014 countsByYear W24748480142018 @default.
• W2474848014 countsByYear W24748480142019 @default.
• W2474848014 countsByYear W24748480142021 @default.
• W2474848014 countsByYear W24748480142022 @default.
• W2474848014 countsByYear W24748480142023 @default.
• W2474848014 crossrefType "journal-article" @default.
• W2474848014 hasAuthorship W2474848014A5001265999 @default.
• W2474848014 hasAuthorship W2474848014A5037141307 @default.
• W2474848014 hasAuthorship W2474848014A5041305380 @default.
• W2474848014 hasBestOaLocation W24748480141 @default.
• W2474848014 hasConcept C108625454 @default.
• W2474848014 hasConcept C12554922 @default.
• W2474848014 hasConcept C1491633281 @default.
• W2474848014 hasConcept C170493617 @default.
• W2474848014 hasConcept C185592680 @default.
• W2474848014 hasConcept C206212055 @default.
• W2474848014 hasConcept C2777313579 @default.
• W2474848014 hasConcept C2778106830 @default.
• W2474848014 hasConcept C30324644 @default.
• W2474848014 hasConcept C37088560 @default.
• W2474848014 hasConcept C50254741 @default.
• W2474848014 hasConcept C55493867 @default.
• W2474848014 hasConcept C83743174 @default.
• W2474848014 hasConcept C86803240 @default.
• W2474848014 hasConcept C95444343 @default.
• W2474848014 hasConceptScore W2474848014C108625454 @default.
• W2474848014 hasConceptScore W2474848014C12554922 @default.
• W2474848014 hasConceptScore W2474848014C1491633281 @default.
• W2474848014 hasConceptScore W2474848014C170493617 @default.
• W2474848014 hasConceptScore W2474848014C185592680 @default.
• W2474848014 hasConceptScore W2474848014C206212055 @default.
• W2474848014 hasConceptScore W2474848014C2777313579 @default.
• W2474848014 hasConceptScore W2474848014C2778106830 @default.
• W2474848014 hasConceptScore W2474848014C30324644 @default.
• W2474848014 hasConceptScore W2474848014C37088560 @default.
• W2474848014 hasConceptScore W2474848014C50254741 @default.
• W2474848014 hasConceptScore W2474848014C55493867 @default.
• W2474848014 hasConceptScore W2474848014C83743174 @default.
• W2474848014 hasConceptScore W2474848014C86803240 @default.
• W2474848014 hasConceptScore W2474848014C95444343 @default.
• W2474848014 hasFunder F4320322108 @default.
• W2474848014 hasFunder F4320337346 @default.
• W2474848014 hasIssue "22" @default.
• W2474848014 hasLocation W24748480141 @default.
• W2474848014 hasLocation W24748480142 @default.
• W2474848014 hasLocation W24748480143 @default.
• W2474848014 hasLocation W24748480144 @default.
• W2474848014 hasOpenAccess W2474848014 @default.
• W2474848014 hasPrimaryLocation W24748480141 @default.
• W2474848014 hasRelatedWork W1555877029 @default.

• next