FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474867401> ?p ?o ?g. }

• W2474867401 endingPage "266" @default.
• W2474867401 startingPage "259" @default.
• W2474867401 abstract "We previously confirmed that rats overloaded with aluminum exhibited hepatic function damage and increased susceptibility to hepatic inflammation. However, the mechanism of liver toxicity by chronic aluminum overload is poorly understood. In this study, we investigated changes in the 5-lipoxygenase (5-LO) signaling pathway and its effect on liver injury in aluminum-overloaded rats. A rat hepatic injury model of chronic aluminum injury was established via the intragastric administration of aluminum gluconate (Al3 + 200 mg/kg per day, 5 days a week for 20 weeks). The 5-LO inhibitor, caffeic acid (10 and 30 mg/kg), was intragastrically administered 1 h after aluminum administration. Hematoxylin and eosin staining was used to visualize pathological changes in rat liver tissue. A series of biochemical indicators were measured with biochemistry assay or ELISAs. Immunochemistry and RT-PCR methods were used to detect 5-LO protein and mRNA expression in the liver, respectively. Caffeic acid administration protected livers against histopathological injury, decreased plasma ALT, AST, and ALP levels, decreased TNF-α, IL-6, IL-1β and LTs levels, increased the reactive oxygen species content, and down-regulated the mRNA and protein expressions of 5-LO in aluminum overloaded rats. Our results indicate that 5-lipoxygenase activation is mechanistically involved in chronic hepatic injury in a rat model of chronic aluminum overload exposure and that the 5-LO signaling pathway, which associated with inflammation and oxidative stress, is a potential therapeutic target for chronic non-infection liver diseases." @default.
• W2474867401 created "2016-07-22" @default.
• W2474867401 creator A5018463211 @default.
• W2474867401 creator A5026608977 @default.
• W2474867401 creator A5029053049 @default.
• W2474867401 creator A5049692788 @default.
• W2474867401 creator A5053873921 @default.
• W2474867401 creator A5060752335 @default.
• W2474867401 creator A5060886735 @default.
• W2474867401 creator A5072541326 @default.
• W2474867401 creator A5075430732 @default.
• W2474867401 creator A5082631360 @default.
• W2474867401 date "2016-08-01" @default.
• W2474867401 modified "2023-10-13" @default.
• W2474867401 title "5-lipoxygenase activation is involved in the mechanisms of chronic hepatic injury in a rat model of chronic aluminum overload exposure" @default.
• W2474867401 cites W1538399032 @default.
• W2474867401 cites W1971934134 @default.
• W2474867401 cites W1974797973 @default.
• W2474867401 cites W1974979980 @default.
• W2474867401 cites W1990927501 @default.
• W2474867401 cites W1994803872 @default.
• W2474867401 cites W2005186266 @default.
• W2474867401 cites W2008505856 @default.
• W2474867401 cites W2021392314 @default.
• W2474867401 cites W2021717825 @default.
• W2474867401 cites W2024176341 @default.
• W2474867401 cites W2024481308 @default.
• W2474867401 cites W2041647802 @default.
• W2474867401 cites W2042171286 @default.
• W2474867401 cites W2069037274 @default.
• W2474867401 cites W2082931005 @default.
• W2474867401 cites W2093421042 @default.
• W2474867401 cites W2100043100 @default.
• W2474867401 cites W2102278102 @default.
• W2474867401 cites W2103007042 @default.
• W2474867401 cites W2111584037 @default.
• W2474867401 cites W2116058709 @default.
• W2474867401 cites W2122029685 @default.
• W2474867401 cites W2150668687 @default.
• W2474867401 cites W2150994839 @default.
• W2474867401 cites W2162368537 @default.
• W2474867401 cites W2163552631 @default.
• W2474867401 cites W2165156241 @default.
• W2474867401 cites W2166021655 @default.
• W2474867401 cites W2166745871 @default.
• W2474867401 cites W2172137781 @default.
• W2474867401 cites W4251055760 @default.
• W2474867401 cites W428944122 @default.
• W2474867401 doi "https://doi.org/10.1016/j.taap.2016.06.029" @default.
• W2474867401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27368151" @default.
• W2474867401 hasPublicationYear "2016" @default.
• W2474867401 type Work @default.
• W2474867401 sameAs 2474867401 @default.
• W2474867401 citedByCount "16" @default.
• W2474867401 countsByYear W24748674012017 @default.
• W2474867401 countsByYear W24748674012018 @default.
• W2474867401 countsByYear W24748674012019 @default.
• W2474867401 countsByYear W24748674012020 @default.
• W2474867401 countsByYear W24748674012022 @default.
• W2474867401 countsByYear W24748674012023 @default.
• W2474867401 crossrefType "journal-article" @default.
• W2474867401 hasAuthorship W2474867401A5018463211 @default.
• W2474867401 hasAuthorship W2474867401A5026608977 @default.
• W2474867401 hasAuthorship W2474867401A5029053049 @default.
• W2474867401 hasAuthorship W2474867401A5049692788 @default.
• W2474867401 hasAuthorship W2474867401A5053873921 @default.
• W2474867401 hasAuthorship W2474867401A5060752335 @default.
• W2474867401 hasAuthorship W2474867401A5060886735 @default.
• W2474867401 hasAuthorship W2474867401A5072541326 @default.
• W2474867401 hasAuthorship W2474867401A5075430732 @default.
• W2474867401 hasAuthorship W2474867401A5082631360 @default.
• W2474867401 hasConcept C125473707 @default.
• W2474867401 hasConcept C126322002 @default.
• W2474867401 hasConcept C134018914 @default.
• W2474867401 hasConcept C185592680 @default.
• W2474867401 hasConcept C204232928 @default.
• W2474867401 hasConcept C2776151105 @default.
• W2474867401 hasConcept C2776637226 @default.
• W2474867401 hasConcept C2776914184 @default.
• W2474867401 hasConcept C2780942790 @default.
• W2474867401 hasConcept C71924100 @default.
• W2474867401 hasConcept C98274493 @default.
• W2474867401 hasConceptScore W2474867401C125473707 @default.
• W2474867401 hasConceptScore W2474867401C126322002 @default.
• W2474867401 hasConceptScore W2474867401C134018914 @default.
• W2474867401 hasConceptScore W2474867401C185592680 @default.
• W2474867401 hasConceptScore W2474867401C204232928 @default.
• W2474867401 hasConceptScore W2474867401C2776151105 @default.
• W2474867401 hasConceptScore W2474867401C2776637226 @default.
• W2474867401 hasConceptScore W2474867401C2776914184 @default.
• W2474867401 hasConceptScore W2474867401C2780942790 @default.
• W2474867401 hasConceptScore W2474867401C71924100 @default.
• W2474867401 hasConceptScore W2474867401C98274493 @default.
• W2474867401 hasLocation W24748674011 @default.
• W2474867401 hasLocation W24748674012 @default.
• W2474867401 hasOpenAccess W2474867401 @default.
• W2474867401 hasPrimaryLocation W24748674011 @default.
• W2474867401 hasRelatedWork W1966504330 @default.

• next