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• W2474868486 abstract "Epidemiologic studies indicate that coffee consumption reduces the risk of Parkinson's disease and Alzheimer's disease. To determine the factors involved, we examined the protective effects of coffee components. The test involved prevention of neurotoxicity to SH-SY5Y cells that was induced by lipopolysaccharide plus interferon-γ or interferon-γ released from activated microglia and astrocytes. We found that quercetin, flavones, chlorogenic acid, and caffeine protected SH-SY5Y cells from these toxins. They also reduced the release of tumor necrosis factor-α and interleukin-6 from the activated microglia and astrocytes and attenuated the activation of proteins from P38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa light chain enhancer of activated B cells (NFκB). After exposure to toxin containing glial-stimulated conditioned medium, we also found that quercetin reduced oxidative/nitrative damage to DNA, as well as to the lipids and proteins of SH-SY5Y cells. There was a resultant increase in [GSH]i in SH-SY5Y cells. The data indicate that quercetin is the major neuroprotective component in coffee against Parkinson's disease and Alzheimer's disease." @default.
• W2474868486 created "2016-07-22" @default.
• W2474868486 creator A5003771168 @default.
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• W2474868486 date "2016-10-01" @default.
• W2474868486 modified "2023-10-16" @default.
• W2474868486 title "Quercetin, not caffeine, is a major neuroprotective component in coffee" @default.
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• W2474868486 doi "https://doi.org/10.1016/j.neurobiolaging.2016.06.015" @default.
• W2474868486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27479153" @default.
• W2474868486 hasPublicationYear "2016" @default.
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