Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474877000> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2474877000 endingPage "20" @default.
- W2474877000 startingPage "15" @default.
- W2474877000 abstract "Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in the detection of DNA strand termini. Extensive cellular damage can overactivate PARP-1, which rapidly depletes the cellular stores of NAD+ and ATP, resulting in necrotic cell death. The purpose of the present study was to determine whether 6(5H)-phenanthridinone, a potent inhibitor of PARP-1, could attenuate the hepatotoxicity of carbon tetrachloride (CCl4). Male ICR mice treated via the intraperitoneal route with CCl4 exhibited severe necrotic centrilobular lesions and significantly elevated serum transaminases. In contrast, the histopathology and serum biochemistry of animals treated concomitantly with CCl4 and 6(5H)-phenanthridinone were not significantly different versus controls. In conclusion, the results of this study demonstrate that the hepatotoxicity of CCl4 can be blocked independently of its metabolism and suggest the predominant role of PARP-1 overactivation in chemical-induced toxicity." @default.
- W2474877000 created "2016-07-22" @default.
- W2474877000 creator A5015621773 @default.
- W2474877000 creator A5024186876 @default.
- W2474877000 creator A5032179414 @default.
- W2474877000 creator A5047913901 @default.
- W2474877000 creator A5049021416 @default.
- W2474877000 creator A5056681959 @default.
- W2474877000 creator A5079206027 @default.
- W2474877000 date "2004-01-01" @default.
- W2474877000 modified "2023-09-26" @default.
- W2474877000 title "Hepatoprotective effects of 6(5H)-phenanthridinone from chemical-induced centrilobular necrosis." @default.
- W2474877000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17564302" @default.
- W2474877000 hasPublicationYear "2004" @default.
- W2474877000 type Work @default.
- W2474877000 sameAs 2474877000 @default.
- W2474877000 citedByCount "2" @default.
- W2474877000 countsByYear W24748770002012 @default.
- W2474877000 crossrefType "journal-article" @default.
- W2474877000 hasAuthorship W2474877000A5015621773 @default.
- W2474877000 hasAuthorship W2474877000A5024186876 @default.
- W2474877000 hasAuthorship W2474877000A5032179414 @default.
- W2474877000 hasAuthorship W2474877000A5047913901 @default.
- W2474877000 hasAuthorship W2474877000A5049021416 @default.
- W2474877000 hasAuthorship W2474877000A5056681959 @default.
- W2474877000 hasAuthorship W2474877000A5079206027 @default.
- W2474877000 hasConcept C102124568 @default.
- W2474877000 hasConcept C142724271 @default.
- W2474877000 hasConcept C153911025 @default.
- W2474877000 hasConcept C178790620 @default.
- W2474877000 hasConcept C181199279 @default.
- W2474877000 hasConcept C182979987 @default.
- W2474877000 hasConcept C185592680 @default.
- W2474877000 hasConcept C2777359374 @default.
- W2474877000 hasConcept C2779864607 @default.
- W2474877000 hasConcept C29730261 @default.
- W2474877000 hasConcept C503630168 @default.
- W2474877000 hasConcept C544855455 @default.
- W2474877000 hasConcept C55493867 @default.
- W2474877000 hasConcept C71924100 @default.
- W2474877000 hasConcept C82381507 @default.
- W2474877000 hasConcept C86803240 @default.
- W2474877000 hasConcept C98274493 @default.
- W2474877000 hasConceptScore W2474877000C102124568 @default.
- W2474877000 hasConceptScore W2474877000C142724271 @default.
- W2474877000 hasConceptScore W2474877000C153911025 @default.
- W2474877000 hasConceptScore W2474877000C178790620 @default.
- W2474877000 hasConceptScore W2474877000C181199279 @default.
- W2474877000 hasConceptScore W2474877000C182979987 @default.
- W2474877000 hasConceptScore W2474877000C185592680 @default.
- W2474877000 hasConceptScore W2474877000C2777359374 @default.
- W2474877000 hasConceptScore W2474877000C2779864607 @default.
- W2474877000 hasConceptScore W2474877000C29730261 @default.
- W2474877000 hasConceptScore W2474877000C503630168 @default.
- W2474877000 hasConceptScore W2474877000C544855455 @default.
- W2474877000 hasConceptScore W2474877000C55493867 @default.
- W2474877000 hasConceptScore W2474877000C71924100 @default.
- W2474877000 hasConceptScore W2474877000C82381507 @default.
- W2474877000 hasConceptScore W2474877000C86803240 @default.
- W2474877000 hasConceptScore W2474877000C98274493 @default.
- W2474877000 hasLocation W24748770001 @default.
- W2474877000 hasLocation W24748770002 @default.
- W2474877000 hasOpenAccess W2474877000 @default.
- W2474877000 hasPrimaryLocation W24748770001 @default.
- W2474877000 hasRelatedWork W1505098675 @default.
- W2474877000 hasRelatedWork W2023012102 @default.
- W2474877000 hasRelatedWork W2032459022 @default.
- W2474877000 hasRelatedWork W2046188958 @default.
- W2474877000 hasRelatedWork W2049882619 @default.
- W2474877000 hasRelatedWork W2068880725 @default.
- W2474877000 hasRelatedWork W2134824763 @default.
- W2474877000 hasRelatedWork W2136348782 @default.
- W2474877000 hasRelatedWork W2161862524 @default.
- W2474877000 hasRelatedWork W2283663091 @default.
- W2474877000 hasRelatedWork W2465692307 @default.
- W2474877000 hasRelatedWork W2530903711 @default.
- W2474877000 hasRelatedWork W2888531326 @default.
- W2474877000 hasRelatedWork W2889092112 @default.
- W2474877000 hasRelatedWork W2897257288 @default.
- W2474877000 hasRelatedWork W3011419693 @default.
- W2474877000 hasRelatedWork W3121868151 @default.
- W2474877000 hasRelatedWork W3140456744 @default.
- W2474877000 hasRelatedWork W3177663394 @default.
- W2474877000 hasRelatedWork W3212606556 @default.
- W2474877000 isParatext "false" @default.
- W2474877000 isRetracted "false" @default.
- W2474877000 magId "2474877000" @default.
- W2474877000 workType "article" @default.