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- W2474881104 abstract "IneukaryoticcellstheTATA-bindingprotein (TBP) associates with other proteins known as TBP- associated factors (TAFs) to form multisubunit transcription factors important for gene expression by all three nuclear RNA polymerases. Computer searching of the complete Sac- charomyces cerevisiaegenome revealed five previously uniden- tified yeast genes with significant sequence similarity to knownhumanandDrosophilaRNApolymeraseIITAFs.Each of these genes is essential for viability. A sixth essential gene (FUN81) has previously been noted to be similar to human TAFII18. Coimmunoprecipitation experiments show that all sixproteinsareassociatedwithTBP,demonstratingthatthey are true TAFs. Furthermore, these proteins are present in complexes containing the TAFII130 subunit, indicating that they are components of TFIID. Based on their predicted molecular weights, these genes have been designated TAF67, TAF61(68), TAF40, TAF23(25), TAF19(FUN81), and TAF17. Yeast TAF61 is significantly larger than its higher eukaryotic homologues, and deletion analysis demonstrates that the evolutionarily conserved, histone-like domain is sufficient and necessary to support viability." @default.
- W2474881104 created "2016-07-22" @default.
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- W2474881104 date "1996-01-01" @default.
- W2474881104 modified "2023-09-27" @default.
- W2474881104 title "Yeast homologues of higher eukaryotic TFIID subunits" @default.
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