FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474906923> ?p ?o ?g. }

• W2474906923 endingPage "18" @default.
• W2474906923 startingPage "1708" @default.
• W2474906923 abstract "Ginseng and its components exert various biological effects, including antioxidant, anti-carcinogenic, anti-mutagenic, and antitumor activity. Ginsenosides are the main biological components of ginseng. Protopanaxadiol (PPD) and protopanaxatriol (PPT) are two metabolites of ginsenosides. However, the difference between these compounds in anti-lung cancer is unclear. The present study aimed to evaluate the antitumor activity of PPD, PPT, Ginsenosides-Rg3 (G-Rg3) and Ginsenosides-Rh2 (G-Rh2) in lung cancer cell. After treatment with cisplatin, PPD, PPT, G-Rg3 or G-Rh2, the viability, apoptosis level and invasiveness of lung cell lines (A549 cell, a lung adenocarcinoma cell line and SK-MES-1 cell, a lung squamous cell line) in vitro were analyzed by Cell Counting Kit-8 (CCK8), Annexin V/PI apoptosis and Matrigel invasion assays, respectively. Here we found that all these compounds led to significant decreases of viability and invasiveness and an obvious increase of apoptosis of A549 and SK-MES-1 cells. Among these, the viability of SK-MES-1 cell treated with PPT was decreased to 66.8%, and this effect was closest to Cisplatin. G-Rg3 had the highest stimulatory effect on apoptosis, and PTT had the highest inhibitory effect on cell invasiveness in A549 and SK-MES-1 cells. These results indicate that both ginsenosides and two metabolites have antitumor activity on lung cancer cell in vitro. However, PPT is more powerful for inhibiting the viability and invasiveness of lung cancer cell, especially lung squamous cell. G-Rg3 has the best pro-apoptosis effects. This study provides a scientific basis for potential therapeutic strategies targeted to lung cancer by further structure modification." @default.
• W2474906923 created "2016-07-22" @default.
• W2474906923 creator A5001547762 @default.
• W2474906923 creator A5011121799 @default.
• W2474906923 creator A5042682690 @default.
• W2474906923 creator A5065325845 @default.
• W2474906923 creator A5085213135 @default.
• W2474906923 creator A5087491415 @default.
• W2474906923 date "2016-01-01" @default.
• W2474906923 modified "2023-09-27" @default.
• W2474906923 title "The antitumor activity study of ginsenosides and metabolites in lung cancer cell." @default.
• W2474906923 cites W125536496 @default.
• W2474906923 cites W139728060 @default.
• W2474906923 cites W1880062250 @default.
• W2474906923 cites W1969075192 @default.
• W2474906923 cites W1972018679 @default.
• W2474906923 cites W1984938280 @default.
• W2474906923 cites W1987365863 @default.
• W2474906923 cites W1996852003 @default.
• W2474906923 cites W2003838432 @default.
• W2474906923 cites W2009221926 @default.
• W2474906923 cites W2021270710 @default.
• W2474906923 cites W2036231707 @default.
• W2474906923 cites W2036437997 @default.
• W2474906923 cites W2040061280 @default.
• W2474906923 cites W2040161487 @default.
• W2474906923 cites W2042122759 @default.
• W2474906923 cites W2055048861 @default.
• W2474906923 cites W2066595295 @default.
• W2474906923 cites W2072618284 @default.
• W2474906923 cites W2079990274 @default.
• W2474906923 cites W2083416941 @default.
• W2474906923 cites W2084406716 @default.
• W2474906923 cites W2096224929 @default.
• W2474906923 cites W2098214643 @default.
• W2474906923 cites W2108255861 @default.
• W2474906923 cites W2109694492 @default.
• W2474906923 cites W2110238320 @default.
• W2474906923 cites W2127787692 @default.
• W2474906923 cites W2129670590 @default.
• W2474906923 cites W2142921795 @default.
• W2474906923 cites W2147629038 @default.
• W2474906923 cites W2154127669 @default.
• W2474906923 cites W2155916998 @default.
• W2474906923 cites W2156109781 @default.
• W2474906923 cites W2158924895 @default.
• W2474906923 cites W2167544841 @default.
• W2474906923 cites W2181959917 @default.
• W2474906923 cites W2212041110 @default.
• W2474906923 cites W349819525 @default.
• W2474906923 cites W4237798718 @default.
• W2474906923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4859899" @default.
• W2474906923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27186294" @default.
• W2474906923 hasPublicationYear "2016" @default.
• W2474906923 type Work @default.
• W2474906923 sameAs 2474906923 @default.
• W2474906923 citedByCount "20" @default.
• W2474906923 countsByYear W24749069232016 @default.
• W2474906923 countsByYear W24749069232017 @default.
• W2474906923 countsByYear W24749069232018 @default.
• W2474906923 countsByYear W24749069232019 @default.
• W2474906923 countsByYear W24749069232020 @default.
• W2474906923 countsByYear W24749069232022 @default.
• W2474906923 countsByYear W24749069232023 @default.
• W2474906923 crossrefType "journal-article" @default.
• W2474906923 hasAuthorship W2474906923A5001547762 @default.
• W2474906923 hasAuthorship W2474906923A5011121799 @default.
• W2474906923 hasAuthorship W2474906923A5042682690 @default.
• W2474906923 hasAuthorship W2474906923A5065325845 @default.
• W2474906923 hasAuthorship W2474906923A5085213135 @default.
• W2474906923 hasAuthorship W2474906923A5087491415 @default.
• W2474906923 hasConcept C126322002 @default.
• W2474906923 hasConcept C142724271 @default.
• W2474906923 hasConcept C1491633281 @default.
• W2474906923 hasConcept C185592680 @default.
• W2474906923 hasConcept C190283241 @default.
• W2474906923 hasConcept C204787440 @default.
• W2474906923 hasConcept C2776256026 @default.
• W2474906923 hasConcept C2776694085 @default.
• W2474906923 hasConcept C2778239845 @default.
• W2474906923 hasConcept C2779232237 @default.
• W2474906923 hasConcept C502942594 @default.
• W2474906923 hasConcept C53227056 @default.
• W2474906923 hasConcept C54355233 @default.
• W2474906923 hasConcept C55493867 @default.
• W2474906923 hasConcept C62112901 @default.
• W2474906923 hasConcept C71924100 @default.
• W2474906923 hasConcept C81729549 @default.
• W2474906923 hasConcept C81885089 @default.
• W2474906923 hasConcept C86803240 @default.
• W2474906923 hasConcept C88634738 @default.
• W2474906923 hasConcept C98274493 @default.
• W2474906923 hasConceptScore W2474906923C126322002 @default.
• W2474906923 hasConceptScore W2474906923C142724271 @default.
• W2474906923 hasConceptScore W2474906923C1491633281 @default.
• W2474906923 hasConceptScore W2474906923C185592680 @default.
• W2474906923 hasConceptScore W2474906923C190283241 @default.
• W2474906923 hasConceptScore W2474906923C204787440 @default.

• next