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• W2474914139 abstract "Background Use of antipsychotics to treat behavioural symptoms of dementia has been associated with increased risks of mortality and stroke. Little is known about individual patient characteristics that might be associated with bad or good outcomes. Aims We examined the risperidone clinical trial data to look for individual patient characteristics associated with these adverse outcomes. Method Data from all double-blind randomised controlled trials of risperidone in dementia patients (risperidone n = 1009, placebo n = 712) were included. Associations between characteristics and outcome were analysed based on crude incidences and exposure-adjusted incidence rates, and by time-to-event analyses using Cox proportional hazards regression. Interactions between treatment (risperidone or placebo) and characteristic were analysed with a Cox proportional hazards regression model with main effects for treatment and characteristic in addition to the interaction term. Results Baseline complications of depression (treatment by risk factor interaction on cerebrovascular adverse event (CVAE) hazard ratio (HR): P = 0.025) and delusions ( P = 0.043) were associated with a lower relative risk of CVAE in risperidone-treated patients (HR = 1.47 and 0.54, respectively) compared to not having the complication (HR = 5.88 and 4.16). For mortality, the only significant baseline predictor in patients treated with risperidone was depression, which was associated with a lower relative risk ( P <0.001). The relative risk of mortality was increased in risperidone patients treated with anti-inflammatory medications ( P = 0.021). Conclusions Only anti-inflammatory medications increased mortality risk with risperidone. The reduced risks of CVAE in patients with comorbid depression and delusions, and of mortality with depression, may have clinical implications when weighing the benefits and risks of treatment with risperidone in patients with dementia." @default.
• W2474914139 created "2016-07-22" @default.
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• W2474914139 date "2016-11-01" @default.
• W2474914139 modified "2023-10-17" @default.
• W2474914139 title "Baseline characteristics and treatment-emergent risk factors associated with cerebrovascular event and death with risperidone in dementia patients" @default.
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• W2474914139 doi "https://doi.org/10.1192/bjp.bp.115.177683" @default.
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