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- W2474914654 abstract "MicroRNAs (miRNAs) are known to function as negative gene regulators. Recently, miRNAs have been shown to regulate immunity processes; however, the mechanism is unclear. The role of microRNA-214 (miR-214) in dendritic cell (DC) maturation has not been investigated. We found that the miR-214 level was correlated with the maturation of DCs and inflammatory cytokine secretion, as depressed miR-214 levels induced DC tolerance. We also identified β-catenin as a target gene of miR-214 and demonstrated its association with Treg cell differentiation. MiR-214 regulates gene expression by binding to the 3'UTR of β-catenin. The results suggest that β-catenin is a critical regulator of tolerance in DCs via miR-214. The expression of miR-214 could be a potential therapeutic strategy in organ transplantation or autoimmunity patients." @default.
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- W2474914654 date "2015-01-01" @default.
- W2474914654 modified "2023-10-18" @default.
- W2474914654 title "MicroRNA-214 induces dendritic cell switching from tolerance to immunity by targeting β-Catenin signaling." @default.
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- W2474914654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4637527" @default.
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