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• W2474925022 abstract "Previous work demonstrated that EAE induced by recombinant human MOG was B cell-dependent. Data presented here reveal a T cell response to MOG61-85 in human rMOG-immunized B cell-/- mice not observed in WT mice. Further study revealed this peptide to be a cryptic epitope in WT mice. Co-immunization of B cell-/- mice with MOG35-55 and MOG61-85 peptides led to less severe disease compared to mice immunized with MOG35-55 alone. Disease amelioration was associated with decreased production of Interferon-γ by lymph node cells. Thus, MOG61-85 represents a protective epitope to human rMOG induced EAE in B cell-/- mice." @default.
• W2474925022 created "2016-07-22" @default.
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• W2474925022 date "2016-11-01" @default.
• W2474925022 modified "2023-09-27" @default.
• W2474925022 title "Amelioration of EAE by a cryptic epitope of myelin oligodendrocyte glycoprotein" @default.
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• W2474925022 doi "https://doi.org/10.1016/j.jneuroim.2016.06.006" @default.
• W2474925022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5097007" @default.
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