FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W247496781> ?p ?o ?g. }

• W247496781 endingPage "467" @default.
• W247496781 startingPage "459" @default.
• W247496781 abstract "Zuojin Pill (ZJP), a traditional Chinese medicinal decoction, contains two herbal drugs: Coptis chinensis Franch. and Tetradium ruticarpum (A. Juss.) Hartley in the ratio of 6:1 (w/w). In this study, ZJP was evaluated for its gastroprotective potential against mucosal lesions induced by ethanol in mice. 50 mice were assigned to 5 groups: groups 1 and 2 were given distilled water orally. Group 3 was administered omeprazole 20 mg/kg, groups 4 and 5 were given ZJP (1 g/kg, 2 g/kg, respectively). After an additional hour, the mice in groups 2–5 received ethanol (0.2 ml/kg) orally while group 1 received distilled water instead. Mice were killed after 4 h and their serum and stomachs subjected to further studies. The superoxidase dismutase (SOD) activities and malondialdehyde (MDA) level in serum were assayed by SOD and MDA kits, respectively. The myeloperoxidase (MPO) activities in stomachs were assayed by MPO kit. The levels of inflammatory mediators including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in serum were assayed by enzyme-linked immunosorbent assay method (ELISA). Pathological changes were observed by hematoxylin-eosin (HE) staining. The levels of nuclear factor-кBp65 (NF-кBp65), P-NF-кBp65, P-IкBα, IкBα, P-IKKα, IKKα, P-IKKβ, IKKβ in stomachs were assayed by western blot. The data showed that treatment with the ZJP markedly attenuated MPO, MDA, TNF-α, IL-6, IL-1βand increased SOD; and ZJP also decreased protein levels of P-NF-кBp65, P-IкBα, P-IKKαand P-IKKβin gastric stomachs. It was concluded that ZJP may represents a potential therapeutic option to reduce the risk of gastric ulceration and the gastroprotective activity of ZJP might contribute in adjusting the inflammatory cytokine by regulating the NF-кB signaling pathway." @default.
• W247496781 created "2016-06-24" @default.
• W247496781 creator A5002591588 @default.
• W247496781 creator A5015968273 @default.
• W247496781 creator A5024417199 @default.
• W247496781 creator A5033498789 @default.
• W247496781 creator A5037677450 @default.
• W247496781 date "2015-09-01" @default.
• W247496781 modified "2023-09-25" @default.
• W247496781 title "Anti-ulcerogenic effect of Zuojin Pill against ethanol-induced acute gastric lesion in animal models" @default.
• W247496781 cites W100235837 @default.
• W247496781 cites W1993855168 @default.
• W247496781 cites W2008854574 @default.
• W247496781 cites W2034367487 @default.
• W247496781 cites W2053096137 @default.
• W247496781 cites W2054899660 @default.
• W247496781 cites W2061514911 @default.
• W247496781 cites W2070398215 @default.
• W247496781 cites W2077062444 @default.
• W247496781 cites W2087047553 @default.
• W247496781 cites W2088314860 @default.
• W247496781 cites W2090937503 @default.
• W247496781 cites W2091003360 @default.
• W247496781 cites W2122925130 @default.
• W247496781 cites W2166781237 @default.
• W247496781 cites W2213239530 @default.
• W247496781 cites W75708282 @default.
• W247496781 cites W89075765 @default.
• W247496781 doi "https://doi.org/10.1016/j.jep.2015.04.017" @default.
• W247496781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25959443" @default.
• W247496781 hasPublicationYear "2015" @default.
• W247496781 type Work @default.
• W247496781 sameAs 247496781 @default.
• W247496781 citedByCount "33" @default.
• W247496781 countsByYear W2474967812015 @default.
• W247496781 countsByYear W2474967812016 @default.
• W247496781 countsByYear W2474967812017 @default.
• W247496781 countsByYear W2474967812019 @default.
• W247496781 countsByYear W2474967812020 @default.
• W247496781 countsByYear W2474967812021 @default.
• W247496781 countsByYear W2474967812022 @default.
• W247496781 countsByYear W2474967812023 @default.
• W247496781 crossrefType "journal-article" @default.
• W247496781 hasAuthorship W247496781A5002591588 @default.
• W247496781 hasAuthorship W247496781A5015968273 @default.
• W247496781 hasAuthorship W247496781A5024417199 @default.
• W247496781 hasAuthorship W247496781A5033498789 @default.
• W247496781 hasAuthorship W247496781A5037677450 @default.
• W247496781 hasConcept C104317684 @default.
• W247496781 hasConcept C126322002 @default.
• W247496781 hasConcept C142724271 @default.
• W247496781 hasConcept C185592680 @default.
• W247496781 hasConcept C188947578 @default.
• W247496781 hasConcept C190409667 @default.
• W247496781 hasConcept C203565725 @default.
• W247496781 hasConcept C204787440 @default.
• W247496781 hasConcept C2775838275 @default.
• W247496781 hasConcept C2776151105 @default.
• W247496781 hasConcept C2776415932 @default.
• W247496781 hasConcept C2776914184 @default.
• W247496781 hasConcept C2777073116 @default.
• W247496781 hasConcept C2778401633 @default.
• W247496781 hasConcept C55493867 @default.
• W247496781 hasConcept C556039675 @default.
• W247496781 hasConcept C71924100 @default.
• W247496781 hasConcept C98274493 @default.
• W247496781 hasConceptScore W247496781C104317684 @default.
• W247496781 hasConceptScore W247496781C126322002 @default.
• W247496781 hasConceptScore W247496781C142724271 @default.
• W247496781 hasConceptScore W247496781C185592680 @default.
• W247496781 hasConceptScore W247496781C188947578 @default.
• W247496781 hasConceptScore W247496781C190409667 @default.
• W247496781 hasConceptScore W247496781C203565725 @default.
• W247496781 hasConceptScore W247496781C204787440 @default.
• W247496781 hasConceptScore W247496781C2775838275 @default.
• W247496781 hasConceptScore W247496781C2776151105 @default.
• W247496781 hasConceptScore W247496781C2776415932 @default.
• W247496781 hasConceptScore W247496781C2776914184 @default.
• W247496781 hasConceptScore W247496781C2777073116 @default.
• W247496781 hasConceptScore W247496781C2778401633 @default.
• W247496781 hasConceptScore W247496781C55493867 @default.
• W247496781 hasConceptScore W247496781C556039675 @default.
• W247496781 hasConceptScore W247496781C71924100 @default.
• W247496781 hasConceptScore W247496781C98274493 @default.
• W247496781 hasLocation W2474967811 @default.
• W247496781 hasLocation W2474967812 @default.
• W247496781 hasOpenAccess W247496781 @default.
• W247496781 hasPrimaryLocation W2474967811 @default.
• W247496781 hasRelatedWork W1990447376 @default.
• W247496781 hasRelatedWork W2041257525 @default.
• W247496781 hasRelatedWork W2106072534 @default.
• W247496781 hasRelatedWork W2360386157 @default.
• W247496781 hasRelatedWork W2366487690 @default.
• W247496781 hasRelatedWork W2372738852 @default.
• W247496781 hasRelatedWork W2382773458 @default.
• W247496781 hasRelatedWork W4281566553 @default.
• W247496781 hasRelatedWork W4303437387 @default.
• W247496781 hasRelatedWork W4365802299 @default.

• next