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- W2474979897 abstract "Fusion proteins are recombinant molecules that combine a targeting mechanism to a cytocidal moiety. DAB 389 IL-2 (denileukin diftitox; ONTAKTM), with a unique mechanism of action, is the first genetically constructed fusion protein to reach the clinic. In this molecule, the interleukin-2 (IL-2) gene is genetically fused to the enzymatically active and translocating domains of diphtheria toxin. DAB 389 IL-2 is internalized into IL-2 receptor-bearing cells by endocytosis. The ADP-ribosyltransferase activity of diphtheria toxin is cleaved in the endosome and is translocated into the cytosol where it inhibits protein synthesis, leading to apoptosis. DAB 389 IL-2 and its predecessor, DAB 486 IL2, have shown clinical activity in a variety of diseases, including B-cell non-Hodgkin’s lymphoma, cutaneous T-cell lymphoma (CTCL), Hodgkin’s disease, psoriasis, rheumatoid arthritis, and HIV infection. The highest response rates were observed in CTCL, and this became the focus of clinical trials leading to its subsequent approval by the United States Food and Drug Administration for this disease. The potential applications of DAB 389 IL-2 in lymphomas are reviewed." @default.
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- W2474979897 date "2000-01-01" @default.
- W2474979897 modified "2023-09-27" @default.
- W2474979897 title "A Novel Fusion Toxin Therapy for Lymphoma" @default.
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