Matches in SemOpenAlex for { <https://semopenalex.org/work/W2474986257> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2474986257 endingPage "84" @default.
- W2474986257 startingPage "779" @default.
- W2474986257 abstract "Bone marrow transplantation has become the therapeutic method in some forms of malignant haemotopoietic diseases, malignant tumours, inborn errors of metabolism and immunodeficiency states. The objective of the presented work is the analysis of 40 allogenic bone marrow transplantations in children made in 1989-1994.Bone marrow transplantation was made in 40 children (26 boys and 14 girls), mean age 10.5 years (range 1.5-17.5 years). Indications were acute lymphoblastic leukaemia in 11, acute myeloid leukaemia in 10, chronic myeloid leukaemia in 6, myelodysplastic syndrome in 2, aplastic anaemia and Fanconi's anaemia in 7, non-Hodgkin lymphoma in 2 and inborn errors in 2 children. The donor was in 33 patients in HLA identical sibling and in seven instances a monozygotic twin, HLA non-identical sibling or relative or unrelated matched donor. Bone marrow engraftment was achieved in 35 (87.5%) patients, in one instance the bone marrow was rejected (2.5%) and in four patients (10%) early death occurred before the bone marrow engraftment. On Aug. 15, 1995 20 patients (50%) survived, a relapse developed in 7 (17.5%) and 13 patients died in conjunction with the transplantation (32.5%). The most frequent cause of death were infectious complications (9 children) either in conjunction with the development of graft versus host reaction (6x) or without signs of this reaction (3x). As a prophylaxis of graft versus host disease 24x Cyclosporine A with corticosteroids was used, 16x with methotrexate. A chronic graft versus host disease developed in 6 of 28 children surviving 100 days after transplantation. The greatest problem are infectious (bacterial and mycotic) complications in the phase of bone marrow aplasia before engraftment of the transplanted bone marrow or in conjunction with a graft versus host reaction which cannot be completely avoided by preventive measures.Bone marrow transplantation is also in children an effective therapeutic method of some forms of malignant haematopoietic diseases, malignant tumours and immunodeficiency states. The correct indication, suitable donor, preventive measures against the graft versus host reaction and protection against infectious complications are essential for the success of this pretentious treatment." @default.
- W2474986257 created "2016-07-22" @default.
- W2474986257 creator A5010166467 @default.
- W2474986257 creator A5010372361 @default.
- W2474986257 creator A5028110023 @default.
- W2474986257 creator A5030169076 @default.
- W2474986257 creator A5031974992 @default.
- W2474986257 creator A5054904756 @default.
- W2474986257 creator A5062125188 @default.
- W2474986257 creator A5077098392 @default.
- W2474986257 creator A5081636923 @default.
- W2474986257 creator A5087509834 @default.
- W2474986257 date "1995-12-13" @default.
- W2474986257 modified "2023-10-17" @default.
- W2474986257 title "[Allogenic transplantation of bone marrow in childhood]." @default.
- W2474986257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8599820" @default.
- W2474986257 hasPublicationYear "1995" @default.
- W2474986257 type Work @default.
- W2474986257 sameAs 2474986257 @default.
- W2474986257 citedByCount "0" @default.
- W2474986257 crossrefType "journal-article" @default.
- W2474986257 hasAuthorship W2474986257A5010166467 @default.
- W2474986257 hasAuthorship W2474986257A5010372361 @default.
- W2474986257 hasAuthorship W2474986257A5028110023 @default.
- W2474986257 hasAuthorship W2474986257A5030169076 @default.
- W2474986257 hasAuthorship W2474986257A5031974992 @default.
- W2474986257 hasAuthorship W2474986257A5054904756 @default.
- W2474986257 hasAuthorship W2474986257A5062125188 @default.
- W2474986257 hasAuthorship W2474986257A5077098392 @default.
- W2474986257 hasAuthorship W2474986257A5081636923 @default.
- W2474986257 hasAuthorship W2474986257A5087509834 @default.
- W2474986257 hasConcept C138496976 @default.
- W2474986257 hasConcept C141071460 @default.
- W2474986257 hasConcept C15744967 @default.
- W2474986257 hasConcept C187212893 @default.
- W2474986257 hasConcept C203014093 @default.
- W2474986257 hasConcept C2776194465 @default.
- W2474986257 hasConcept C2779282312 @default.
- W2474986257 hasConcept C2780007613 @default.
- W2474986257 hasConcept C2781440808 @default.
- W2474986257 hasConcept C2911091166 @default.
- W2474986257 hasConcept C2994180119 @default.
- W2474986257 hasConcept C71924100 @default.
- W2474986257 hasConceptScore W2474986257C138496976 @default.
- W2474986257 hasConceptScore W2474986257C141071460 @default.
- W2474986257 hasConceptScore W2474986257C15744967 @default.
- W2474986257 hasConceptScore W2474986257C187212893 @default.
- W2474986257 hasConceptScore W2474986257C203014093 @default.
- W2474986257 hasConceptScore W2474986257C2776194465 @default.
- W2474986257 hasConceptScore W2474986257C2779282312 @default.
- W2474986257 hasConceptScore W2474986257C2780007613 @default.
- W2474986257 hasConceptScore W2474986257C2781440808 @default.
- W2474986257 hasConceptScore W2474986257C2911091166 @default.
- W2474986257 hasConceptScore W2474986257C2994180119 @default.
- W2474986257 hasConceptScore W2474986257C71924100 @default.
- W2474986257 hasIssue "24" @default.
- W2474986257 hasLocation W24749862571 @default.
- W2474986257 hasOpenAccess W2474986257 @default.
- W2474986257 hasPrimaryLocation W24749862571 @default.
- W2474986257 hasRelatedWork W138120245 @default.
- W2474986257 hasRelatedWork W1488822117 @default.
- W2474986257 hasRelatedWork W2013568308 @default.
- W2474986257 hasRelatedWork W2118777447 @default.
- W2474986257 hasRelatedWork W2337085710 @default.
- W2474986257 hasRelatedWork W2415041261 @default.
- W2474986257 hasRelatedWork W2418821493 @default.
- W2474986257 hasRelatedWork W2434193381 @default.
- W2474986257 hasRelatedWork W2610880980 @default.
- W2474986257 hasRelatedWork W2773845209 @default.
- W2474986257 hasVolume "134" @default.
- W2474986257 isParatext "false" @default.
- W2474986257 isRetracted "false" @default.
- W2474986257 magId "2474986257" @default.
- W2474986257 workType "article" @default.