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• W2475009298 startingPage "1004" @default.
• W2475009298 abstract "Melanoma, which is increasing in incidence, is the most lethal skin cancer. Risk factors for melanoma include genotypic and phenotypicc haracteristics combined with environmental exposures. Germline mutations in CDKN2A and CDK4 are thought to confer high susceptibility for melanoma. Polymorphisms in the melanocortin receptor-1 gene, which is central to melanin synthesis, confer low susceptibility for melanoma. In addition to germline alterations, somatic mutations in either BRAF or NRAS mutations have been found in a high percentage of melanomas. Nevi, which are one of the strongest risk factors for melanoma, also have BRAF mutations. Prevention, early diagnosis, and treatment remain important areas for future advancements." @default.
• W2475009298 created "2016-07-22" @default.
• W2475009298 creator A5042965766 @default.
• W2475009298 date "2007-11-17" @default.
• W2475009298 modified "2023-09-26" @default.
• W2475009298 title "Melanoma and Nevi" @default.
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• W2475009298 doi "https://doi.org/10.1007/978-1-59259-963-9_103" @default.
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