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- W2475026798 abstract "Understanding the natural history of a disease is an important prerequisite for designing studies that assess the impact of interventions, both chemotherapeutic and environmental, on the initiation and expression of the condition. Identification of biomarkers that mark disease progression may provide important indicators for drug targets and surrogate outcomes for clinical trials. However, collecting and visualizing data on natural history is challenging, in part, because disease processes are complex and evolve in different chronological periods for different subjects. Various epidemiological designs are used to elucidate components of the natural history process. We briefly discuss statistical issues, limitations, and challenges associated with various epidemiological designs." @default.
- W2475026798 created "2016-07-22" @default.
- W2475026798 creator A5035612280 @default.
- W2475026798 date "2016-08-18" @default.
- W2475026798 modified "2023-09-29" @default.
- W2475026798 title "Natural history of diseases: Statistical designs and issues" @default.
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- W2475026798 doi "https://doi.org/10.1002/cpt.423" @default.
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