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• W2475175089 startingPage "351" @default.
• W2475175089 abstract "The biology of nickel has been widely studied in mammals because of its carcinogenic properties, whereas few studies have been performed in microorganisms. In the present work, changes accompanying stress caused by nickel were evaluated at the cellular level using RNA-Seq in Escherichia coli K-12. Interestingly, a very large number of genes were found to be deregulated by Ni stress. Iron and oxidative stress homeostasis maintenance were among the most highly enriched functional categories, and genes involved in periplasmic copper efflux were among the most highly upregulated. These results suggest that the deregulation of Fe and Cu homeostatic genes is caused by a release of free Cu and Fe ions in the cell which in turn activate the Cu and Fe homeostatic systems. The content of Cu was not significantly affected upon the addition of Ni to the growth medium, nor were the Cus and CopA Cu-efflux systems important for the survival of bacteria under Ni stress In contrast the addition of Ni slightly decreased the amount of cellular Fe and activated the transcription of Fur regulated genes in a Fur-dependent manner. Cu or Fe imbalance together with oxidative stress might affect the structure of DNA. Further experiments revealed that Ni alters the state of DNA folding by causing a relaxed conformation, a phenomenon that is reversible by addition of the antioxidant Tiron or the Fe chelator Dip. The Tiron-reversible DNA relaxation was also observed for Fe and to a lesser extent with Cu but not with Co. DNA supercoiling is well recognized as an integral aspect of gene regulation. Moreover our results show that Ni modifies the expression of several nucleoid-associated proteins (NAPs), important agents of DNA topology and global gene regulation. This is the first report describing the impact of metal-induced oxidative on global regulatory networks." @default.
• W2475175089 created "2016-07-22" @default.
• W2475175089 creator A5007298245 @default.
• W2475175089 creator A5037411679 @default.
• W2475175089 creator A5054811690 @default.
• W2475175089 date "2016-08-01" @default.
• W2475175089 modified "2023-10-18" @default.
• W2475175089 title "Ni exposure impacts the pool of free Fe and modifies DNA supercoiling via metal-induced oxidative stress in Escherichia coli K-12" @default.
• W2475175089 cites W1483119117 @default.
• W2475175089 cites W1557508370 @default.
• W2475175089 cites W1603612324 @default.
• W2475175089 cites W1616066464 @default.
• W2475175089 cites W1898563571 @default.
• W2475175089 cites W1908829967 @default.
• W2475175089 cites W1964849120 @default.
• W2475175089 cites W1966521314 @default.
• W2475175089 cites W1969887535 @default.
• W2475175089 cites W1974161161 @default.
• W2475175089 cites W1974939001 @default.
• W2475175089 cites W1982245868 @default.
• W2475175089 cites W1991586169 @default.
• W2475175089 cites W1995732138 @default.
• W2475175089 cites W1998744111 @default.
• W2475175089 cites W1999691755 @default.
• W2475175089 cites W2001055223 @default.
• W2475175089 cites W2002144817 @default.
• W2475175089 cites W2010972281 @default.
• W2475175089 cites W2015720118 @default.
• W2475175089 cites W2015806444 @default.
• W2475175089 cites W2016160555 @default.
• W2475175089 cites W2020541351 @default.
• W2475175089 cites W2022897538 @default.
• W2475175089 cites W2029464576 @default.
• W2475175089 cites W2030313390 @default.
• W2475175089 cites W2030830758 @default.
• W2475175089 cites W2032320053 @default.
• W2475175089 cites W2032438852 @default.
• W2475175089 cites W2035530075 @default.
• W2475175089 cites W2037256916 @default.
• W2475175089 cites W2042686872 @default.
• W2475175089 cites W2042735004 @default.
• W2475175089 cites W2043192607 @default.
• W2475175089 cites W2044465376 @default.
• W2475175089 cites W2045873169 @default.
• W2475175089 cites W2048086807 @default.
• W2475175089 cites W2048553024 @default.
• W2475175089 cites W2049336067 @default.
• W2475175089 cites W2050711776 @default.
• W2475175089 cites W2052134382 @default.
• W2475175089 cites W2053537544 @default.
• W2475175089 cites W2064874365 @default.
• W2475175089 cites W2065081503 @default.
• W2475175089 cites W2066159932 @default.
• W2475175089 cites W2069480047 @default.
• W2475175089 cites W2075853257 @default.
• W2475175089 cites W2078635599 @default.
• W2475175089 cites W2078735798 @default.
• W2475175089 cites W2081745487 @default.
• W2475175089 cites W2083022493 @default.
• W2475175089 cites W2088167775 @default.
• W2475175089 cites W2090583425 @default.
• W2475175089 cites W2096046927 @default.
• W2475175089 cites W2096063115 @default.
• W2475175089 cites W2096976702 @default.
• W2475175089 cites W2097951502 @default.
• W2475175089 cites W2097970036 @default.
• W2475175089 cites W2099540110 @default.
• W2475175089 cites W2105770217 @default.
• W2475175089 cites W2105786325 @default.
• W2475175089 cites W2107018762 @default.
• W2475175089 cites W2112271889 @default.
• W2475175089 cites W2114463509 @default.
• W2475175089 cites W2119338907 @default.
• W2475175089 cites W2120391576 @default.
• W2475175089 cites W2127444913 @default.
• W2475175089 cites W2134517495 @default.
• W2475175089 cites W2138139328 @default.
• W2475175089 cites W2140665078 @default.
• W2475175089 cites W2145765526 @default.
• W2475175089 cites W2147990023 @default.
• W2475175089 cites W2148212192 @default.
• W2475175089 cites W2154159254 @default.
• W2475175089 cites W2154488487 @default.
• W2475175089 cites W2162403259 @default.
• W2475175089 cites W2165152213 @default.
• W2475175089 cites W2185874306 @default.
• W2475175089 cites W2511297414 @default.
• W2475175089 cites W4240969190 @default.
• W2475175089 doi "https://doi.org/10.1016/j.freeradbiomed.2016.06.030" @default.
• W2475175089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27375130" @default.
• W2475175089 hasPublicationYear "2016" @default.
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