FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2475201253> ?p ?o ?g. }

• W2475201253 abstract "Desi-type chickpeas, which have long been used as a natural treatment for diabetes, have been reported to lower visceral adiposity, dyslipidemia and insulin resistance induced by a chronic high-fat diet in rats. In this study, in order to examine the effects of chickpeas of this type in an in vitro system, we used the 3T3-L1 mouse cell line, a subclone of Swiss 3T3 cells, which can differentiate into cells with an adipocyte-like phenotype, and we used ethanol extracts of chickpeas (ECP) instead of chickpeas. Treatment of the 3T3-L1 cells with ECP led to a decrease in the lipid content in the cells. The desaturation index, defined as monounsaturated fatty acids (MUFAs)/saturated fatty acids (SFAs), was also decreased by ECP due to an increase in the cellular content of SFAs and a decrease in the content of MUFAs. The decrease in this index may reflect a decreased reaction from SFA to MUFA, which is essential for fat storage. To confirm this hypothesis, we conducted a western blot analysis, which revealed a reduction in the amount of stearoyl-CoA desaturase 1 (SCD1), a key enzyme catalyzing the reaction from SFA to MUFA. We observed simultaneous inactivations of enzymes participating in lipogenesis, i.e., liver kinase B1 (LKB1), acetyl-CoA carboxylase (ACC) and AMPK, by phosphorylation, which may lead to the suppression of reactions from acetyl-CoA to SFA via malonyl-CoA in lipogenesis. We also investigated whether lipolysis is affected by ECP. The amount of carnitine palmitoyltransferase 1 (CPT1), an enzyme important for the oxidation of fatty acids, was increased by ECP treatment. ECP also led to an increase in uncoupling protein 2 (UCP2), reported as a key protein for the oxidation of fatty acids. All of these results obtained regarding lipogenesis and fatty acid metabolism in our in vitro system are consistent with the results previously shown in rats. We also examined the effects on SCD1 and lipid contents of ethanol extracts of Kabuli-type chickpeas, which are used worldwide. The effects were similar, but of much lesser magnitude compared to those of ECP described above. Thus, Desi-type chickpeas may prove to be effective for the treatment of diabetes, as they can alter the lipid content, thus reducing fat storage." @default.
• W2475201253 created "2016-07-22" @default.
• W2475201253 creator A5002096786 @default.
• W2475201253 creator A5020082587 @default.
• W2475201253 creator A5028568416 @default.
• W2475201253 creator A5034127226 @default.
• W2475201253 creator A5036834366 @default.
• W2475201253 creator A5056516932 @default.
• W2475201253 creator A5058636714 @default.
• W2475201253 creator A5064113444 @default.
• W2475201253 creator A5078807619 @default.
• W2475201253 date "2016-06-24" @default.
• W2475201253 modified "2023-10-01" @default.
• W2475201253 title "Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes" @default.
• W2475201253 cites W1546868324 @default.
• W2475201253 cites W1563676220 @default.
• W2475201253 cites W1580210275 @default.
• W2475201253 cites W1878535762 @default.
• W2475201253 cites W1895078941 @default.
• W2475201253 cites W1911193726 @default.
• W2475201253 cites W1927710737 @default.
• W2475201253 cites W1939477527 @default.
• W2475201253 cites W1967667786 @default.
• W2475201253 cites W1970692155 @default.
• W2475201253 cites W1978679812 @default.
• W2475201253 cites W1988232132 @default.
• W2475201253 cites W1990278643 @default.
• W2475201253 cites W1992678387 @default.
• W2475201253 cites W1996381086 @default.
• W2475201253 cites W2003004094 @default.
• W2475201253 cites W2006849116 @default.
• W2475201253 cites W2011738776 @default.
• W2475201253 cites W2012905896 @default.
• W2475201253 cites W2015832516 @default.
• W2475201253 cites W2023430066 @default.
• W2475201253 cites W2040917885 @default.
• W2475201253 cites W2042942822 @default.
• W2475201253 cites W2054661998 @default.
• W2475201253 cites W2063086702 @default.
• W2475201253 cites W2067096633 @default.
• W2475201253 cites W2073346921 @default.
• W2475201253 cites W2076572520 @default.
• W2475201253 cites W2079861885 @default.
• W2475201253 cites W2091673549 @default.
• W2475201253 cites W2106636803 @default.
• W2475201253 cites W2107568093 @default.
• W2475201253 cites W2112115104 @default.
• W2475201253 cites W2113317108 @default.
• W2475201253 cites W2115340562 @default.
• W2475201253 cites W2115589168 @default.
• W2475201253 cites W2121085406 @default.
• W2475201253 cites W2127187614 @default.
• W2475201253 cites W2127265700 @default.
• W2475201253 cites W2128517000 @default.
• W2475201253 cites W2134535786 @default.
• W2475201253 cites W2136715884 @default.
• W2475201253 cites W2138202978 @default.
• W2475201253 cites W2145084780 @default.
• W2475201253 cites W2147099129 @default.
• W2475201253 cites W2148323125 @default.
• W2475201253 cites W2161595876 @default.
• W2475201253 cites W2162692698 @default.
• W2475201253 cites W2164514101 @default.
• W2475201253 cites W2168814200 @default.
• W2475201253 cites W2188976671 @default.
• W2475201253 cites W2620406790 @default.
• W2475201253 cites W2916596946 @default.
• W2475201253 cites W1966509583 @default.
• W2475201253 doi "https://doi.org/10.3892/ijmm.2016.2654" @default.
• W2475201253 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4935453" @default.
• W2475201253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27353085" @default.
• W2475201253 hasPublicationYear "2016" @default.
• W2475201253 type Work @default.
• W2475201253 sameAs 2475201253 @default.
• W2475201253 citedByCount "8" @default.
• W2475201253 countsByYear W24752012532018 @default.
• W2475201253 countsByYear W24752012532019 @default.
• W2475201253 countsByYear W24752012532020 @default.
• W2475201253 countsByYear W24752012532021 @default.
• W2475201253 countsByYear W24752012532023 @default.
• W2475201253 crossrefType "journal-article" @default.
• W2475201253 hasAuthorship W2475201253A5002096786 @default.
• W2475201253 hasAuthorship W2475201253A5020082587 @default.
• W2475201253 hasAuthorship W2475201253A5028568416 @default.
• W2475201253 hasAuthorship W2475201253A5034127226 @default.
• W2475201253 hasAuthorship W2475201253A5036834366 @default.
• W2475201253 hasAuthorship W2475201253A5056516932 @default.
• W2475201253 hasAuthorship W2475201253A5058636714 @default.
• W2475201253 hasAuthorship W2475201253A5064113444 @default.
• W2475201253 hasAuthorship W2475201253A5078807619 @default.
• W2475201253 hasBestOaLocation W24752012531 @default.
• W2475201253 hasConcept C126322002 @default.
• W2475201253 hasConcept C134018914 @default.
• W2475201253 hasConcept C140137476 @default.
• W2475201253 hasConcept C140985366 @default.
• W2475201253 hasConcept C141359234 @default.
• W2475201253 hasConcept C171089720 @default.
• W2475201253 hasConcept C181199279 @default.
• W2475201253 hasConcept C184235292 @default.
• W2475201253 hasConcept C2776175234 @default.

• next