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• W2475271036 startingPage "971" @default.
• W2475271036 abstract "Various strategies have been proposed for the sensing of acetylcholinesterase (AChE) activity and organophosphorus pesticides (OPs). However, the practical application of most methods is restricted by their intrinsic drawbacks such as complexity, long analysis time, and high cost. Thus, it is highly desirable to develop simple, fast and sensitive approaches for AChE activity and OPs detection. Herein, we reported a simple paper-based fluorescent sensor (PFS) based on the aggregation induced emission (AIE) effect of tetraphenylethylene (TPE) and the addition reaction capability of maleimide, which has been used as a powerful tool for rapid naked-eye detection of AChE activity and OPs. The introduction of TPE provides the probe with unique fluorescence property in solid state and is of great importance for improving the sensitivity of PFS. The hydrolysis product of acetylthiocholine catalyzed by AChE induced the maleimide ring destruction and activated the fluorescence performance of TPE. Given that AChE activity can be specifically inhibited by OPs, the as-proposed PFS can also be utilized for sensitive detection of OPs. Meanwhile, the variation of fluorescence signal can be readily detected by naked eyes, and low detection limits of 2.5 mU mL−1 and 0.5 ng mL−1 for AChE activity and OPs are obtained, respectively. Moreover, it has been successfully applied for AChE activity and OPs detection in diluted human serum samples, showing its great potential to be applied in real samples. Thus, this strategy possesses considerable advantages of simplicity, rapid detection, portability, cost efficiency and visualization." @default.
• W2475271036 created "2016-07-22" @default.
• W2475271036 creator A5019127626 @default.
• W2475271036 creator A5063907835 @default.
• W2475271036 creator A5071346021 @default.
• W2475271036 creator A5081844561 @default.
• W2475271036 date "2016-12-01" @default.
• W2475271036 modified "2023-10-14" @default.
• W2475271036 title "Paper-based fluorescent sensor for rapid naked-eye detection of acetylcholinesterase activity and organophosphorus pesticides with high sensitivity and selectivity" @default.
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• W2475271036 doi "https://doi.org/10.1016/j.bios.2016.07.022" @default.
• W2475271036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27498323" @default.
• W2475271036 hasPublicationYear "2016" @default.
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