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• W2475287362 abstract "We introduce a robust, stable, and reproducible method to produce nanoparticles based on expansion of supercritical solutions using carbon dioxide as a solvent. The method, controlled expansion of supercritical solution (CESS), uses controlled mass transfer, flow, pressure reduction, and particle collection in dry ice. CESS offers control over the crystallization process as the pressure in the system is reduced according to a specific profile. Particle formation takes place before the exit nozzle, and condensation is the main mechanism for postnucleation particle growth. A 2-step gradient pressure reduction is used to prevent Mach disk formation and particle growth by coagulation. Controlled particle growth keeps the production process stable. With CESS, we produced piroxicam nanoparticles, 60 mg/h, featuring narrow size distribution (176 ± 53 nm)." @default.
• W2475287362 created "2016-07-22" @default.
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• W2475287362 date "2016-08-01" @default.
• W2475287362 modified "2023-09-27" @default.
• W2475287362 title "Controlled Expansion of Supercritical Solution: A Robust Method to Produce Pure Drug Nanoparticles With Narrow Size-Distribution" @default.
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• W2475287362 doi "https://doi.org/10.1016/j.xphs.2016.05.022" @default.
• W2475287362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27368121" @default.
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